Defibrotide Activity in Experimental Frostbite Injury
| dc.authorid | Ozyazgan, Irfan/0000-0003-2074-4587 | |
| dc.authorscopusid | 35579240900 | |
| dc.authorscopusid | 56006411800 | |
| dc.authorscopusid | 6701914821 | |
| dc.authorscopusid | 7006476274 | |
| dc.authorscopusid | 7003945496 | |
| dc.authorscopusid | 6603804780 | |
| dc.authorwosid | Ozyazgan, Irfan/U-6431-2018 | |
| dc.contributor.author | Özyazgan, I. | |
| dc.contributor.author | Tercan, M. | |
| dc.contributor.author | Bekerecioǧlu, M. | |
| dc.contributor.author | Melli, M. | |
| dc.contributor.author | Üstün, H. | |
| dc.contributor.author | Günay, G.K. | |
| dc.date.accessioned | 2025-05-10T17:05:16Z | |
| dc.date.available | 2025-05-10T17:05:16Z | |
| dc.date.issued | 1998 | |
| dc.department | T.C. Van Yüzüncü Yıl Üniversitesi | en_US |
| dc.department-temp | Özyazgan I., Med. Faculty of Erciyes University, Kayseri, Turkey; Tercan M., Med. Fac. of Inonü University, Malatya, Turkey, Plastic and Reconstruction Surgery, Med. Fac. of Inönü Univ., Malatya, Turkey; Bekerecioǧlu M., Med. Faculty of 100, Yll University, Van, Turkey, Plastic and Reconstruction Surgery, Medical Faculty of 100, Y11 University, Van, Turkey; Melli M., Med. Faculty of Ankara University, Ankara, Turkey, Department of Pharmacology, Medical Faculty of Ankara University, Ankara, Turkey; Üstün H., Ankara State Hospital, Ankara, Turkey, Department of Pathology, Ankara State Hospital, Ankara, Turkey; Günay G.K., Med. Faculty of Erciyes University, Kayseri, Turkey, Med. Faculty of Erciyes UNiversitty, Kayseri, Turkey | en_US |
| dc.description.abstract | The pathogenesis of frostbite injury has not been completely elucidated although the available evidence suggests it is an inflammatory reaction following reperfusion injury. Defibrotide given i.p. at 40 mg/kg/day for three days to rabbits, the ears of which were subjected to frostbite, decreased the presence of inflammatory cells (mast cells -76%; neutrophils -40.4%) and increased prostaglandin I2 (PGI2) (as 6-Keto-PGF(1α)) in the involved skin. Thromboxane A2 (TxA2) (as TxB2)was unaffected. These data strengthen the view that an inflammatory process is the underlying cause of frostbite injury and that Defibrotide is active in pathological situations involving an inflammatory process like in frostbite. | en_US |
| dc.description.sponsorship | Erciyes University Research Fund; Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET, (SBAG-AYD-4) | en_US |
| dc.description.woscitationindex | Science Citation Index Expanded | |
| dc.identifier.doi | 10.1054/bjps.1997.0061 | |
| dc.identifier.endpage | 454 | en_US |
| dc.identifier.issn | 0007-1226 | |
| dc.identifier.issue | 6 | en_US |
| dc.identifier.pmid | 9849365 | |
| dc.identifier.pmid | 9849365 | |
| dc.identifier.scopus | 2-s2.0-0032168583 | |
| dc.identifier.scopusquality | N/A | |
| dc.identifier.startpage | 450 | en_US |
| dc.identifier.uri | https://doi.org/10.1054/bjps.1997.0061 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14720/6276 | |
| dc.identifier.volume | 51 | en_US |
| dc.identifier.wos | WOS:000076088400007 | |
| dc.identifier.wosquality | N/A | |
| dc.language.iso | en | en_US |
| dc.publisher | Churchill Livingstone | en_US |
| dc.relation.ispartof | British Journal of Plastic Surgery | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.title | Defibrotide Activity in Experimental Frostbite Injury | en_US |
| dc.type | Article | en_US |