Therapeutic Potential of Hesperidin: Apoptosis Induction in Breast Cancer Cell Lines
dc.authorid | Aydin, Funda/0000-0002-5484-9435 | |
dc.authorid | Onder, Gozde Ozge/0000-0002-0515-9286 | |
dc.authorscopusid | 56149556900 | |
dc.authorscopusid | 57062770700 | |
dc.authorscopusid | 55871681600 | |
dc.authorscopusid | 37110595300 | |
dc.authorscopusid | 36912319800 | |
dc.authorscopusid | 55158194400 | |
dc.authorwosid | Önder, Gözde/Jzt-8583-2024 | |
dc.authorwosid | Bitgen, Nazmiye/Aao-8052-2021 | |
dc.authorwosid | Baran, Munevver/Aap-2345-2021 | |
dc.authorwosid | Göktepe, Özge/Aba-4880-2020 | |
dc.authorwosid | Aydin, Funda/W-3076-2017 | |
dc.contributor.author | Onder, Gozde Ozge | |
dc.contributor.author | Goktepe, Ozge | |
dc.contributor.author | Baran, Munevver | |
dc.contributor.author | Bitgen, Nazmiye | |
dc.contributor.author | Aydin, Funda | |
dc.contributor.author | Yaya, Arzu | |
dc.date.accessioned | 2025-05-10T17:21:21Z | |
dc.date.available | 2025-05-10T17:21:21Z | |
dc.date.issued | 2023 | |
dc.department | T.C. Van Yüzüncü Yıl Üniversitesi | en_US |
dc.department-temp | [Onder, Gozde Ozge; Goktepe, Ozge; Yaya, Arzu] Erciyes Univ, Fac Med, Dept Histol & Embryol, TR-38039 Kayseri, Turkiye; [Onder, Gozde Ozge; Goktepe, Ozge; Bitgen, Nazmiye; Yaya, Arzu] Erciyes Univ, Genome & Stem Cell Ctr, Kayseri, Turkiye; [Baran, Munevver] Erciyes Univ, Fac Pharm, Dept Pharmaceut Basic Sci, Kayseri, Turkiye; [Bitgen, Nazmiye] Erciyes Univ, Fac Med, Dept Med Biol, Kayseri, Turkiye; [Aydin, Funda] Van Yuzuncu Yil Univ, Fac Pharm, Dept Basic Sci, Van, Turkiye | en_US |
dc.description | Aydin, Funda/0000-0002-5484-9435; Onder, Gozde Ozge/0000-0002-0515-9286 | en_US |
dc.description.abstract | Hesperidin is a flavonoid commonly found in citrus fruits. Studies have shown that hesperidin has anti-inflammatory, analgesic, and antimicrobial properties, as well as its effectiveness in carcinogenesis. In this paper, we aim to investigate the molecular mechanisms of hesperidin-induced apoptosis in MCF-7 and MDA-MB-231 cancer cells.The inhibitory effect of hesperidin on cellular proliferation was evaluated with the MTT assay. Cell cycle analysis of hesperidin-treated cells was then performed, as well as immunocytochemical analysis of the effect on the apoptosis pathway (TUNEL, Bax, and Bcl-2 expression).Moreover, hesperidin induced cellular apoptosis in MCF-7 breast cancer cells by inhibiting Bcl-2 and enhancing Bax expression at protein levels. On the other hand, hesperidin caused apoptosis in the MDA-MB-231 breast cancer cell line, but it did not activate the Bax/Bcl-2 pathway. Hesperidin also induced cell cycle arrest at the S phase in the MCF-7 and MDA-MB-231 cell lines.These findings showed that hesperidin is a potential therapeutic candidate for preventing the progression of breast cancer. In addition, hesperidin could significantly stimulate the death mechanisms in ER/PR (+) MCF-7 cells by changing the expression balance of Bax and Bcl-2 proteins, but lead ER/PR (-) MDA-MB-231 breast cancer cells to apoptosis in a different way. | en_US |
dc.description.sponsorship | Scientific Research Coordination Unit of Erciyes University, Turkey (EUBAP) [TKB-2020-10305] | en_US |
dc.description.sponsorship | This research was supported by the Scientific Research Coordination Unit of Erciyes University, Turkey (EUBAP, TKB-2020-10305) . | en_US |
dc.description.woscitationindex | Science Citation Index Expanded | |
dc.identifier.doi | 10.1016/j.fct.2023.113791 | |
dc.identifier.issn | 0278-6915 | |
dc.identifier.issn | 1873-6351 | |
dc.identifier.pmid | 37080525 | |
dc.identifier.scopus | 2-s2.0-85153601361 | |
dc.identifier.scopusquality | Q1 | |
dc.identifier.uri | https://doi.org/10.1016/j.fct.2023.113791 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14720/10383 | |
dc.identifier.volume | 176 | en_US |
dc.identifier.wos | WOS:000990353500001 | |
dc.identifier.wosquality | Q1 | |
dc.language.iso | en | en_US |
dc.publisher | Pergamon-elsevier Science Ltd | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Hesperidin | en_US |
dc.subject | Mcf-7 | en_US |
dc.subject | Mda-Mb-231 | en_US |
dc.title | Therapeutic Potential of Hesperidin: Apoptosis Induction in Breast Cancer Cell Lines | en_US |
dc.type | Article | en_US |