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Therapeutic Potential of Hesperidin: Apoptosis Induction in Breast Cancer Cell Lines

dc.authorid Aydin, Funda/0000-0002-5484-9435
dc.authorid Onder, Gozde Ozge/0000-0002-0515-9286
dc.authorscopusid 56149556900
dc.authorscopusid 57062770700
dc.authorscopusid 55871681600
dc.authorscopusid 37110595300
dc.authorscopusid 36912319800
dc.authorscopusid 55158194400
dc.authorwosid Önder, Gözde/Jzt-8583-2024
dc.authorwosid Bitgen, Nazmiye/Aao-8052-2021
dc.authorwosid Baran, Munevver/Aap-2345-2021
dc.authorwosid Göktepe, Özge/Aba-4880-2020
dc.authorwosid Aydin, Funda/W-3076-2017
dc.contributor.author Onder, Gozde Ozge
dc.contributor.author Goktepe, Ozge
dc.contributor.author Baran, Munevver
dc.contributor.author Bitgen, Nazmiye
dc.contributor.author Aydin, Funda
dc.contributor.author Yaya, Arzu
dc.date.accessioned 2025-05-10T17:21:21Z
dc.date.available 2025-05-10T17:21:21Z
dc.date.issued 2023
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Onder, Gozde Ozge; Goktepe, Ozge; Yaya, Arzu] Erciyes Univ, Fac Med, Dept Histol & Embryol, TR-38039 Kayseri, Turkiye; [Onder, Gozde Ozge; Goktepe, Ozge; Bitgen, Nazmiye; Yaya, Arzu] Erciyes Univ, Genome & Stem Cell Ctr, Kayseri, Turkiye; [Baran, Munevver] Erciyes Univ, Fac Pharm, Dept Pharmaceut Basic Sci, Kayseri, Turkiye; [Bitgen, Nazmiye] Erciyes Univ, Fac Med, Dept Med Biol, Kayseri, Turkiye; [Aydin, Funda] Van Yuzuncu Yil Univ, Fac Pharm, Dept Basic Sci, Van, Turkiye en_US
dc.description Aydin, Funda/0000-0002-5484-9435; Onder, Gozde Ozge/0000-0002-0515-9286 en_US
dc.description.abstract Hesperidin is a flavonoid commonly found in citrus fruits. Studies have shown that hesperidin has anti-inflammatory, analgesic, and antimicrobial properties, as well as its effectiveness in carcinogenesis. In this paper, we aim to investigate the molecular mechanisms of hesperidin-induced apoptosis in MCF-7 and MDA-MB-231 cancer cells.The inhibitory effect of hesperidin on cellular proliferation was evaluated with the MTT assay. Cell cycle analysis of hesperidin-treated cells was then performed, as well as immunocytochemical analysis of the effect on the apoptosis pathway (TUNEL, Bax, and Bcl-2 expression).Moreover, hesperidin induced cellular apoptosis in MCF-7 breast cancer cells by inhibiting Bcl-2 and enhancing Bax expression at protein levels. On the other hand, hesperidin caused apoptosis in the MDA-MB-231 breast cancer cell line, but it did not activate the Bax/Bcl-2 pathway. Hesperidin also induced cell cycle arrest at the S phase in the MCF-7 and MDA-MB-231 cell lines.These findings showed that hesperidin is a potential therapeutic candidate for preventing the progression of breast cancer. In addition, hesperidin could significantly stimulate the death mechanisms in ER/PR (+) MCF-7 cells by changing the expression balance of Bax and Bcl-2 proteins, but lead ER/PR (-) MDA-MB-231 breast cancer cells to apoptosis in a different way. en_US
dc.description.sponsorship Scientific Research Coordination Unit of Erciyes University, Turkey (EUBAP) [TKB-2020-10305] en_US
dc.description.sponsorship This research was supported by the Scientific Research Coordination Unit of Erciyes University, Turkey (EUBAP, TKB-2020-10305) . en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.1016/j.fct.2023.113791
dc.identifier.issn 0278-6915
dc.identifier.issn 1873-6351
dc.identifier.pmid 37080525
dc.identifier.scopus 2-s2.0-85153601361
dc.identifier.scopusquality Q1
dc.identifier.uri https://doi.org/10.1016/j.fct.2023.113791
dc.identifier.uri https://hdl.handle.net/20.500.14720/10383
dc.identifier.volume 176 en_US
dc.identifier.wos WOS:000990353500001
dc.identifier.wosquality Q1
dc.language.iso en en_US
dc.publisher Pergamon-elsevier Science Ltd en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Apoptosis en_US
dc.subject Hesperidin en_US
dc.subject Mcf-7 en_US
dc.subject Mda-Mb-231 en_US
dc.title Therapeutic Potential of Hesperidin: Apoptosis Induction in Breast Cancer Cell Lines en_US
dc.type Article en_US

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