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Evaluation of Plasma Agmatine Level and Its Metabolic Pathway in Patients With Bipolar Disorder During Manic Episode and Remission Period

dc.authorscopusid 57208777970
dc.authorscopusid 6603300537
dc.authorscopusid 56180040900
dc.authorscopusid 56389653700
dc.authorwosid Yilmaz, Emine/Aba-3523-2020
dc.authorwosid Sekeroglu, Ramazan/Htn-6390-2023
dc.authorwosid Çokluk, Erdem/Aib-9278-2022
dc.contributor.author Yilmaz, Emine
dc.contributor.author Sekeroglu, M. Ramazan
dc.contributor.author Yilmaz, Ekrem
dc.contributor.author Cokluk, Erdem
dc.date.accessioned 2025-05-10T17:34:14Z
dc.date.available 2025-05-10T17:34:14Z
dc.date.issued 2019
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Yilmaz, Emine; Cokluk, Erdem] Van Yuzuncu Yil Univ, Fac Med, Dept Biochem, Van, Turkey; [Sekeroglu, M. Ramazan] Sakarya Univ, Fac Med, Dept Biochem, Sakarya, Turkey; [Yilmaz, Ekrem] Hlth Sci Univ, Van Training & Res Hosp, Dept Psychiat, Van, Turkey en_US
dc.description.abstract Objectives: Agmatine is a cationic amine resulting from the decarboxylation of l-arginine. Agmatine has neuroprotective, anti-inflammatory, anti-stress, and anti-depressant properties. In this study, plasma agmatine, arginine decarboxylase, and agmatinase levels were measured during manic episode and remission period in patients with bipolar disorder. Methods: Thirty healthy volunteers and 30 patients who meet Bipolar Disorder Manic Episode diagnostic criteria were included in the study. Additionally, the changes in the patient group between manic episode and remission period were examined. We evaluated the relationship between levels of l-arginine and arginine decarboxylase in the agmatine synthesis pathway, and level of agmatinase that degrades agmatine. Results: Levels of agmatine and l-arginine were significantly increased than control group during manic episode (p < .01). All parameters were increased during manic episode compared to remission period (p < .05). Agmatinase was significantly decreased both during manic episode (p < .01) and remission period (p < .05) in comparison to the control group. Arginine decarboxylase levels did not show a significant difference between the groups (p > .05). Conclusions: This study indicate that there may be a relationship between bipolar disorder and agmatine and its metabolic pathway. Nonetheless, we believe more comprehensive studies are needed in order to reveal the role of agmatine in etiology of bipolar disorder. en_US
dc.description.sponsorship Yuzuncu Yil University Scientific Research Project [2015-TFU-0296] en_US
dc.description.sponsorship This work was supported by the Yuzuncu Yil University Scientific Research Project [grant numbers 2015-TFU-0296]. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.1080/13651501.2019.1569237
dc.identifier.endpage 133 en_US
dc.identifier.issn 1365-1501
dc.identifier.issn 1471-1788
dc.identifier.issue 2 en_US
dc.identifier.pmid 31081413
dc.identifier.scopus 2-s2.0-85065799389
dc.identifier.scopusquality Q2
dc.identifier.startpage 128 en_US
dc.identifier.uri https://doi.org/10.1080/13651501.2019.1569237
dc.identifier.uri https://hdl.handle.net/20.500.14720/13728
dc.identifier.volume 23 en_US
dc.identifier.wos WOS:000470442500001
dc.identifier.wosquality Q3
dc.language.iso en en_US
dc.publisher Taylor & Francis Ltd en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Agmatine en_US
dc.subject Bipolar Disorder en_US
dc.subject Agmatinase en_US
dc.subject L-Arginine en_US
dc.subject Arginine Decarboxylase en_US
dc.title Evaluation of Plasma Agmatine Level and Its Metabolic Pathway in Patients With Bipolar Disorder During Manic Episode and Remission Period en_US
dc.type Article en_US

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