Intermolecular Heterocyclization of Alkynones With 2-Mercaptoacetaldehyde Under Metal-Free Conditions: Synthesis of 2,3-Disubstituted Thiophenes
No Thumbnail Available
Date
2015
Journal Title
Journal ISSN
Volume Title
Publisher
Pergamon-elsevier Science Ltd
Abstract
A concise and regioselective approach for the synthesis of 2,3-disubstituted thiophene derivatives has been developed. The synthetic strategy relies on the reaction of an in situ generated 2-mercaptoacetaldehyde with various alkynones. Furthermore, we calculated the energy gap between the HOMO and the LUMO orbitals of all compounds and observed that the introduction of a strong electron-withdrawing group decreased the HOMO-LUMO energy gap. (C) 2015 Elsevier Ltd. All rights reserved.
Description
Menges, Nurettin/0000-0002-5990-6275
ORCID
Keywords
Alkynes, Cyclization, Alkynones, 2-Mercaptoacetaldehyde, 2,3-Disubstituted Thiophenes
Turkish CoHE Thesis Center URL
WoS Q
Q3
Scopus Q
Q3
Source
Volume
56
Issue
40
Start Page
5386
End Page
5389