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Gingival Crevicular Fluid Levels of Human Beta-Defensin and Cathelicidin in Smoker and Non-Smoker Patients: a Cross-Sectional Study

dc.authorid Alpaslan, Nazli Zeynep/0000-0002-6311-385X
dc.authorid Bozoglan, Alihan/0000-0003-3420-5816
dc.authorid Sahin Aydinyurt, Hacer/0000-0002-9521-9704
dc.authorscopusid 55317580600
dc.authorscopusid 57192604857
dc.authorscopusid 55317812900
dc.authorscopusid 55317572200
dc.authorscopusid 55317812800
dc.authorscopusid 55539572500
dc.authorwosid Bozoğlan, Alihan/W-4773-2018
dc.authorwosid Dikilitas, Ahu/Kba-3180-2024
dc.authorwosid Alpaslan, Nazli Zeynep/Gry-5635-2022
dc.contributor.author Ertugrul, A. S.
dc.contributor.author Sahin, H.
dc.contributor.author Dikilitas, A.
dc.contributor.author Alpaslan, N. Z.
dc.contributor.author Bozoglan, A.
dc.contributor.author Tekin, Y.
dc.date.accessioned 2025-05-10T17:44:06Z
dc.date.available 2025-05-10T17:44:06Z
dc.date.issued 2014
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Ertugrul, A. S.; Sahin, H.; Dikilitas, A.; Alpaslan, N. Z.; Bozoglan, A.; Tekin, Y.] Yuzuncu Yil Univ, Dept Periodontol, Fac Dent, Van, Turkey en_US
dc.description Alpaslan, Nazli Zeynep/0000-0002-6311-385X; Bozoglan, Alihan/0000-0003-3420-5816; Sahin Aydinyurt, Hacer/0000-0002-9521-9704 en_US
dc.description.abstract Background and Objective Cathelicidin (LL-37) and human beta-defensin-2 (hBD-2) are antimicrobial peptides that have additional functions in innate immunity. The purpose of this study was to evaluate LL-37 and hBD-2 levels in the following patient groups: non-smoker patients with gingivitis (G), smoker patients with gingivitis (SG), non-smoker patients with generalized aggressive periodontitis (AgP) and smoker patients with generalized aggressive periodontitis (SAgP). Material and Methods A total of 80 patients, including 20 G, 20 SG, 20 AgP and 20 SAgP were enrolled in the study. Clinical periodontal parameters, including periodontal status were assessed by measuring bleeding on probing, plaque index, gingival index, probing depth and clinical attachment loss. Enzyme-linked immunosorbent assays were done to quantify LL-37 and hBD-2 levels in gingival crevicular fluid. Results Clinical periodontal parameters were found to have no statistically significant differences between the SAgP and AgP groups or between the SG and G groups. LL-37 and hBD-2 levels were significantly lower in G patients than in other groups. LL-37 and hBD-2 levels in the gingival crevicular fluid of SAgP patients were significantly higher than in other groups. LL-37 and hBD-2 levels in SG patients were also significantly higher than in G patients. Conclusions Epithelial cells in contact with microorganisms release LL-37 and hBD-2 to eliminate them. The release response of LL-37 and hBD-2 formed against microorganisms can change depending on factors such as smoking, which activates the nicotinic receptors present on epithelial surfaces. This interaction can increase the release of LL-37 and hBD-2. Smoking may also affect the capillary tissues and reduce leukocytic chemotaxis. The increased number of colonized microorganisms may lead to higher levels of LL-37 and hBD-2 release in the tissues of smokers than in non-smokers. en_US
dc.description.sponsorship University of Yuzuncu Yil University (Committee of Research) [2010-DF-B010]; School of Dentistry, Yuzuncu Yil University en_US
dc.description.sponsorship This study was self-funded by the authors and by The University of Yuzuncu Yil University (Committee of Research 2010-DF-B010). The authors thank School of Dentistry, Yuzuncu Yil University, for support. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.1111/jre.12105
dc.identifier.endpage 289 en_US
dc.identifier.issn 0022-3484
dc.identifier.issn 1600-0765
dc.identifier.issue 3 en_US
dc.identifier.pmid 23721053
dc.identifier.scopus 2-s2.0-84899647086
dc.identifier.scopusquality Q1
dc.identifier.startpage 282 en_US
dc.identifier.uri https://doi.org/10.1111/jre.12105
dc.identifier.uri https://hdl.handle.net/20.500.14720/16078
dc.identifier.volume 49 en_US
dc.identifier.wos WOS:000335007600002
dc.identifier.wosquality Q2
dc.language.iso en en_US
dc.publisher Wiley en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Smoking en_US
dc.subject Cathelicidin en_US
dc.subject Human Beta-Defensin-2 en_US
dc.subject Aggressive Periodontitis en_US
dc.subject Periodontal Disease en_US
dc.title Gingival Crevicular Fluid Levels of Human Beta-Defensin and Cathelicidin in Smoker and Non-Smoker Patients: a Cross-Sectional Study en_US
dc.type Article en_US

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