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The Natural Diatomite From Caldiran-Van (Turkey): Electroanalytical Application To Antimigraine Compound Naratriptan at Modified Carbon Paste Electrode

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Date

2010

Journal Title

Journal ISSN

Volume Title

Publisher

Bentham Science Publ Ltd

Abstract

This paper is the first report describing the characterization of local diatomite of Caldiran-Van region (Eastern Anatolia, Turkey). Special attention was paid to the ability of its electroanalytical performance at modified electrodes and to the potential application of diatomite-modified electrode. For this purpose, the determination of Naratriptan which is a novel oral triptan (5-hydroxytryptamine receptor agonist) in migraine treatment, by means of a carbon paste electrode modified with 10% (w/w) of diatomite was studied using cyclic and square-wave voltammetry. The experimental conditions that affect the electrode reaction process were studied in terms of pH of the supporting electrolyte, scan rate, accumulation variables, modifier composition and square-wave parameters. Using square-wave stripping mode, the drug yielded a well-defined voltammetric response in Britton-Robinson buffer, pH 4.0 at 0.84 V (vs Ag/AgCl) (a pre-concentration step being carried out with an open circuit at 120 s). The process could be used to determine Naratriptan concentrations in the range 5x10(-7)-9x10(-7) M, with a detection limit of 1.25x10(-7) M (46.5 mu g L(-1)). The applicability of the method to spiked human urine samples was illustrated.

Description

Senturk, Zuhre/0000-0002-0356-9345; Yardim, Yavuz/0000-0002-9587-096X; Gokirmak Sogut, Eda/0000-0002-7707-3924; Saka, Cafer/0000-0003-2534-5921

Keywords

Diatomite, Characterization, Modified Carbon Paste Electrode, Cyclic Voltammetry, Square-Wave Stripping Voltammetry, Naratriptan, Urine

Turkish CoHE Thesis Center URL

WoS Q

Q3

Scopus Q

Q3

Source

Volume

13

Issue

8

Start Page

703

End Page

711