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Insulin Resistance Is Increased in Patients With Vitiligo

dc.authorscopusid 26425048800
dc.authorscopusid 55903409200
dc.authorscopusid 9280148200
dc.authorwosid Karadag, Ayse/V-7974-2018
dc.contributor.author Karadag, Ayse Serap
dc.contributor.author Tutal, Emre
dc.contributor.author Ertugrul, Derun Taner
dc.date.accessioned 2025-05-10T17:26:23Z
dc.date.available 2025-05-10T17:26:23Z
dc.date.issued 2011
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Karadag, Ayse Serap] Yuzuncu Yil Univ, Fac Med, Dept Dermatol, TR-65300 Van, Turkey; [Tutal, Emre] Ankara Baskent Univ Hosp, Dept Internal Med, Fac Med, Ankara, Turkey; [Ertugrul, Derun Taner] Ankara Kecioren Res & Training Hosp, Div Endocrinol & Metab, Dept Internal Med, Ankara, Turkey en_US
dc.description.abstract The aim of this study was to evaluate the relationship between vitiligo and insulin resistance (IR). A total of 96 subjects were included in the study; 57 patients with vitiligo and 39 subjects in an age and a body mass index-matched control group. In fasting blood samples, insulin, C-peptide, glucose, total cholesterol, triglyceride, low-density lipoprotein-cholesterol (LDL-C) and high-density lipoprotein-cholesterol (HDL-C) were measured. IR was calculated with the homeostasis model assessment-IR (HOMA-IR) method. Comparison of the vitiligo and the control groups revealed that patients with vitiligo had higher IR (2.3 vs. 2.0,p<0.01), higher insulin and C-peptide levels (p<0.001, p<0.001, respectively), higher LDL/HDL ratio and lower HDL-C levels (p<0.01, p<0.0001, respectively). Systolic blood pressures of patients with vitiligo were also higher compared with control subjects (p<0.01). Further experimental and clinical studies are needed to elucidate the molecular mechanisms underlying this association. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.2340/00015555-1141
dc.identifier.endpage 544 en_US
dc.identifier.issn 0001-5555
dc.identifier.issn 1651-2057
dc.identifier.issue 5 en_US
dc.identifier.pmid 21597678
dc.identifier.scopus 2-s2.0-80052067435
dc.identifier.scopusquality Q1
dc.identifier.startpage 541 en_US
dc.identifier.uri https://doi.org/10.2340/00015555-1141
dc.identifier.uri https://hdl.handle.net/20.500.14720/11661
dc.identifier.volume 91 en_US
dc.identifier.wos WOS:000294887800009
dc.identifier.wosquality Q1
dc.language.iso en en_US
dc.publisher Acta dermato-venereologica en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Homa-Ir en_US
dc.subject Insulin Resistance en_US
dc.subject Vitiligo en_US
dc.title Insulin Resistance Is Increased in Patients With Vitiligo en_US
dc.type Article en_US

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