Oxidative Stress Has a Negative Effect on the Development and Progression of Bladder Cancer

Abstract

OBJECTIVE In this study, we aimed to investigate the oxidant-antioxidant capacity in bladder cancer according to invasion and degree. METHODS Forty-six patients with bladder cancer and 50 healthy volunteers were included in the study. After 12 h of fasting, 4cc of blood venous blood was taken from these patients. Then, after centrifugation at 5000 rpms for 10 min, the serum portion of the study was completed. The activities of arylesterase (ARE), paraoxanase-1 (PON-1), glutathione reductase (GR), glutathione-S transferase, and protein carbonyl (PC) in serum were measured spectrophotometrically. RESULTS Antioxidant parameters in the serum of patients with bladder tumors were found lower than control group (p=0.001). In addition, PC was found to be higher in the bladder cancer group than in the control group (p=0.001); on the other hand, ARE, PON-1, and GR levels were found to be lower in both high-grade tumors and invasive tumors (p <=.0.05). CONCLUSION Oxidative stress is effective in the development and progression of bladder tumors.