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Anthocyanin-Rich Extract From Hibiscus Sabdariffa Calyx Counteracts Uvc-Caused Impairments in Rats

dc.authorid Tuluce, Yasin/0000-0002-7312-5934
dc.authorid Koyuncu, Ismail/0000-0002-9469-4757
dc.authorid Dilsiz, Nihat/0000-0002-0612-435X
dc.authorscopusid 54179576500
dc.authorscopusid 57203094952
dc.authorscopusid 10143414500
dc.authorscopusid 6701329336
dc.authorscopusid 56780419400
dc.authorscopusid 36574004100
dc.authorwosid Koyuncu, Ismail/Abf-8907-2020
dc.authorwosid Tuluce, Yasin/S-6812-2016
dc.authorwosid Dilsiz, Nihat/Cai-0100-2022
dc.contributor.author Ozkol, Hatice Uce
dc.contributor.author Koyuncu, Ismail
dc.contributor.author Tuluce, Yasin
dc.contributor.author Dilsiz, Nihat
dc.contributor.author Soral, Sinan
dc.contributor.author Ozkol, Halil
dc.date.accessioned 2025-05-10T17:42:42Z
dc.date.available 2025-05-10T17:42:42Z
dc.date.issued 2015
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Ozkol, Hatice Uce] Yuzuncu Yil Univ, Fac Med, Dept Dermatol, Van, Turkey; [Koyuncu, Ismail; Soral, Sinan] Harran Univ, Fac Sci, Dept Biol, Sanliurfa, Turkey; [Tuluce, Yasin; Ozkol, Halil] Yuzuncu Yil Univ, Fac Med, Dept Med Biol, Van, Turkey; [Dilsiz, Nihat] Harran Univ, Fac Sci, Dept Mol Biol & Genet, Sanliurfa, Turkey en_US
dc.description Tuluce, Yasin/0000-0002-7312-5934; Koyuncu, Ismail/0000-0002-9469-4757; Dilsiz, Nihat/0000-0002-0612-435X en_US
dc.description.abstract Context: Ultraviolet radiation (UV) was reported to cause oxidative stress. Hibiscus sabdariffa L. (Malvaceae) calyx is commonly used in traditional Asian and African medicines and possesses strong antioxidant capacity due to its anthocyanin (ANTH) content. Objective: This study researched the possible protective role of Hibiscus sabdariffa calyx extract (HSCE) in UVC exposure of rats. Material and methods: Levels of serum enzymes, renal function tests, and some oxidant/antioxidant biomarkers of skin, lens, and retina tissues were monitored. Rats were exposed to UVC 4 h daily for 40 d and simultaneously received HSCE containing 2.5, 5, and 10 mg doses of ANTH in drinking water. Results: Significant (p < 0.05) increases in the levels of serum aminotransferases, lactate dehydrogenase, urea, creatinine, and uric acid were noted after UVC exposure. In skin, lens, and retina tissues, total oxidant status, oxidative stress index, lipid peroxidation, and protein oxidation escalated markedly (p < 0.05) whereas total antioxidant status, reduced glutathione, and superoxide dismutase decreased dramatically (p < 0.05) related to UVC. Co-administration of HSCE with each ANTH dose significantly (p < 0.05) reversed aforementioned parameters (except total oxidant status) almost in all tissues. The LD50 of HSCE in rats was determined to be above 5000 mg/kg. Discussion and conclusion: Our data revealed that HSCE has a remarkable potential to counteract UVC-caused impairments, probably through its antioxidant and free radical-defusing effects. Therefore, HSCE could be useful against some cutaneous and ocular diseases in which UV and oxidative stress have a role in the etiopathogenesis. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.3109/13880209.2014.980586
dc.identifier.endpage 1441 en_US
dc.identifier.issn 1388-0209
dc.identifier.issn 1744-5116
dc.identifier.issue 10 en_US
dc.identifier.pmid 25784105
dc.identifier.scopus 2-s2.0-84939213856
dc.identifier.scopusquality Q2
dc.identifier.startpage 1435 en_US
dc.identifier.uri https://doi.org/10.3109/13880209.2014.980586
dc.identifier.uri https://hdl.handle.net/20.500.14720/15626
dc.identifier.volume 53 en_US
dc.identifier.wos WOS:000361338100002
dc.identifier.wosquality Q1
dc.language.iso en en_US
dc.publisher Taylor & Francis Ltd en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Anthocyanins en_US
dc.subject Lens en_US
dc.subject Oxidative Stress en_US
dc.subject Photoaging en_US
dc.subject Photocarcinogenesis en_US
dc.subject Retina en_US
dc.subject Skin en_US
dc.subject Ultraviolet Radiation en_US
dc.title Anthocyanin-Rich Extract From Hibiscus Sabdariffa Calyx Counteracts Uvc-Caused Impairments in Rats en_US
dc.type Article en_US

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