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Treatment Efficacy of Ribociclib or Palbociclib Plus Letrozole in Hormone Receptor-positive/Her2-negative Metastatic Breast Cancer

dc.authorid Kahraman, Seda/0000-0002-5328-6554
dc.authorid Bayoglu, Ibrahim Vedat/0000-0002-0481-1084
dc.authorid Sahin, Elif/0000-0002-1976-3951
dc.authorid Er, Muhammed Muhiddin/0000-0002-0583-0295
dc.authorid Teker, Fatih/0000-0003-4693-6587
dc.authorid Bilgin, Burak/0000-0003-1717-8246
dc.authorid Aydin, Dincer/0000-0002-7433-3591
dc.authorscopusid 56960020000
dc.authorscopusid 57223009128
dc.authorscopusid 57202053776
dc.authorscopusid 55349813400
dc.authorscopusid 57226407427
dc.authorscopusid 35329601700
dc.authorscopusid 9637671400
dc.authorwosid Sahin, Elif/Jki-7415-2023
dc.authorwosid Teker, Fati̇h/Aah-1005-2020
dc.authorwosid Turhal, Nazim/Aaj-4421-2020
dc.authorwosid Alkan, Ali/Aac-7028-2019
dc.authorwosid Sunar, Veli/Aag-3220-2021
dc.authorwosid Erul, Enes/Agj-5340-2022
dc.authorwosid Erul, Enes/Gqh-6479-2022
dc.contributor.author Kahraman, Seda
dc.contributor.author Erul, Enes
dc.contributor.author Seyyar, Mustafa
dc.contributor.author Gumusay, Ozge
dc.contributor.author Bayram, Ertugrul
dc.contributor.author Demirel, Burcin Cakan
dc.contributor.author Sendur, Mehmet Ali Nahit
dc.date.accessioned 2025-05-10T17:21:27Z
dc.date.available 2025-05-10T17:21:27Z
dc.date.issued 2023
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Kahraman, Seda; Hizal, Mutlu; Erol, Cihan; Yalcin, Bulent; Sendur, Mehmet Ali Nahit] Ankara Yildirim Beyazit Univ, Ankara City Hosp, Dept Med Oncol, TR-06800 Ankara, Turkiye; [Erul, Enes; Aksoy, Sercan; Guven, Deniz Can] Hacettepe Univ, Canc Inst, Dept Med Oncol, TR-06590 Ankara, Turkiye; [Seyyar, Mustafa; Sahin, Elif; Cabuk, Devrim] Kocaeli Univ, Med Fac Hosp, Dept Med Oncol, TR-41000 Kocaeli, Turkiye; [Gumusay, Ozge; Basaran, Gul; Uluc, Basak Oyan] Acibadem Univ, Sch Med, Dept Med Oncol, TR-34750 Istanbul, Turkiye; [Bayram, Ertugrul; Paydas, Semra] Cukurova Univ, Dept Med Oncol, TR-01330 Adana, Turkiye; [Demirel, Burcin Cakan; Yaren, Arzu] Pamukkale Univ Hosp, Dept Med Oncol, TR-20160 Denizli, Turkiye; [Acar, Omer; Erdogan, Atike Pinar] Manisa Celal Bayar Univ Hosp, Dept Med Oncol, TR-45120 Mersin, Turkiye; [Baytemur, Naziyet Kose; Demirci, Umut] Ankara Mem Hosp, Dept Med Oncol, TR-06520 Ankara, Turkiye; [Yasar, Alper; Bayoglu, Ibrahim Vedat] Marmara Univ, Dept Med Oncol, Pendik Res & Applicat Hosp, TR-34899 Istanbul, Turkiye; [Gulbagci, Burcu; Hacibekiroglu, Ilhan] Sakarya Univ, Sch Med, Dept Med Oncol, TR-54187 Sakarya, Turkiye; [Paksoy, Nail; Aydiner, Adnan] Istanbul Univ, Dept Med Oncol, TR-34093 Istanbul, Turkiye; [Davarci, Sena Ece; Demir, Hacer] Afyonkarahisar Hlth Sci Univ, Dept Med Oncol, TR-03200 Afyonkarahisar, Turkiye; [Yilmaz, Funda; Oksuzoglu, Berna] Dr Abdurrahman Yurtaslan Ankara Oncol Training & R, Dept Med Oncol, TR-06200 Ankara, Turkiye; [Dogan, Ozlem; Cilbir, Ebru] Ankara Etlik City Hosp, Dept Med Oncol, TR-06170 Ankara, Turkiye; [Orhan, Sibel Oyucu; Cubukcu, Erdem] Uludag Univ, Dept Med Oncol, TR-16059 Bursa, Turkiye; [Kayikcioglu, Erkan; Cetin, Bulent] Suleyman Demirel Univ, Dept Med Oncol, TR-32260 Isparta, Turkiye; [Aytac, Ali; Oktay, Esin] Aydin Adnan Menderes Univ, Dept Med Oncol, Training & Res Hosp, TR-09100 Aydin, Turkiye; [Keskinkilic, Merve; Yavuzsen, Tugba] Dokuz Eylul Univ, Res & Applicat Hosp, Dept Med Oncol, TR-35340 Izmir, Turkiye; [Mocan, Eda Eylemer] Ankara Univ, Dept Med Oncol, TR-06080 Ankara, Turkiye; [Unal, Olcun Umit; Keser, Murat] Tepecik Training & Res Hosp, Dept Med Oncol, TR-35180 Izmir, Turkiye; [Aydin, Esra] Recep Tayyip Erdogan Univ Training & Res Hosp, Dept Med Oncol, TR-53020 Rize, Turkiye; [Yucel, Hakan; Teker, Fatih] Gaziantep Univ, Dept Med Oncol, TR-27580 Gaziantep, Turkiye; [Isik, Deniz] Kocaeli Med Pk Hosp, Dept Med Oncol, TR-41140 Kocaeli, Turkiye; [Eren, Onder] Selcuk Univ, Dept Med Oncol, Med Fac Hosp, TR-42250 Konya, Turkiye; [Ozcelik, Melike] Umraniye Training & Res Hosp, Dept Med Oncol, TR-34764 Istanbul, Turkiye; [Okutur, Sadi Kerem] Istanbul Arel Univ, Bahcelievler Mem Hosp, Dept Med Oncol, TR-34537 Istanbul, Turkiye; [Yildirim, Nilgun] Firat Univ Hosp, Dept Med Oncol, TR-23200 Elazig, Turkiye; [Alkan, Ali] Mugla Sitki Kocman Univ Training & Res Hosp, Dept Med Oncol, TR-48000 Mugla, Turkiye; [Selcukbiricik, Fatih] Koc Univ Hosp, Dept Med Oncol, TR-34010 Istanbul, Turkiye; [Aksoy, Asude] Elazig Fethi Sekin City Hosp, Dept Med Oncol, TR-23280 Elazig, Turkiye; [Karakas, Yusuf] Acibadem Bodrum Hosp, Dept Med Oncol, TR-48420 Mugla, Turkiye; [Ozkanli, Gulhan] Canakkale Onsekiz Mart Univ, Dept Med Oncol, Res & Practice Hosp, TR-17100 Canakkale, Turkiye; [Duman, Berna Bozkurt] Adana City Training & Res Hosp, Dept Med Oncol, TR-01230 Adana, Turkiye; [Aydin, Dincer] Kocaeli Derince Training & Res Hosp, Dept Med Oncol, TR-41310 Kocaeli, Turkiye; [Dulgar, Ozgecan; Sakalar, Teoman] Kahramanmaras Necip Fazil City Hosp, Dept Med Oncol, TR-46050 Kahramanmaras, Turkiye; [Er, Muhammed Muhiddin] Necmettin Erbakan Univ, Dept Med Oncol, Meram Med Fac Hosp, TR-42080 Konya, Turkiye; [Aykan, Musa Baris; Karadurmus, Nuri] Gulhane Training & Res Hosp, Dept Med Oncol, TR-06010 Ankara, Turkiye; [Inal, Ali] Mersin City Hosp, Dept Med Oncol, TR-96015 Mersin, Turkiye; [Iriagac, Yakup] Namik Kemal Univ, Dept Med Oncol, Hlth Applicat & Res Hosp, TR-59030 Tekirdag, Turkiye; [Kalkan, Nurhan Onal] Van Yuzuncu Yil Univ, Dursun Odabas Hosp, Dept Med Oncol, TR-65090 Van, Turkiye; [Menekse, Serkan; Kut, Engin] Manisa City Hosp, Dept Med Oncol, TR-45040 Manisa, Turkiye; [Bilgin, Burak] Konya City Hosp, Dept Med Oncol, TR-42020 Konya, Turkiye; [Karaoglanoglu, Muge] Ordu State Hosp, Dept Med Oncol, TR-52200 Ordu, Turkiye; [Sunar, Veli] Aydin Ataturk State Hosp, Dept Med Oncol, TR-09020 Aydin, Turkiye; [Ozdemir, Ozlem] Izmir Bozyaka Training & Res Hosp, Dept Med Oncol, TR-35170 Izmir, Turkiye; [Turhal, Nazim Serdar] Anadolu Med Ctr, Dept Med Oncol, TR-34758 Istanbul, Turkiye en_US
dc.description Kahraman, Seda/0000-0002-5328-6554; Bayoglu, Ibrahim Vedat/0000-0002-0481-1084; Sahin, Elif/0000-0002-1976-3951; Er, Muhammed Muhiddin/0000-0002-0583-0295; Teker, Fatih/0000-0003-4693-6587; Bilgin, Burak/0000-0003-1717-8246; Hacibekiroglu, Ilhan/0000-0002-0333-7405; Yavuzsen, Tugba/0000-0001-9375-8133; Dulgar, Ozgecan/0000-0002-0678-4024; Keskinkilic, Merve/0000-0002-3342-3144; Kayikcioglu, Erkan/0000-0002-7401-5446; Aydin, Esra/0000-0003-0210-3153; Oyucu Orhan, Sibel/0000-0001-8217-3471; Bayram, Ertugrul/0000-0001-8713-7613; Erul, Enes/0000-0002-2487-2087; Aydin, Dincer/0000-0002-7433-3591 en_US
dc.description.abstract Background: Ribociclib, palbociclib and abemaciclib are currently approved CDK4/6 inhibitors along with aromatase inhibitors as the first-line standard-of-care for patients with hormone receptor-positive, HER2-negative metastatic breast cancer. Methods: The authors report retrospective real-life data for 600 patients with estrogen receptor- and/or progesterone receptor-positive and HER2-negative metastatic breast cancer who were treated with ribociclib and palbociclib in combination with letrozole. Results & conclusion: The results demonstrated that the combination of palbociclib or ribociclib with letrozole has similar progression-free survival and overall survival benefit in real life for the patient group with similar clinical features. Specifically, endocrine sensitivity may be a factor to be considered in the treatment preference. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.2217/fon-2022-1287
dc.identifier.issn 1479-6694
dc.identifier.issn 1744-8301
dc.identifier.pmid 37133230
dc.identifier.scopus 2-s2.0-85159731947
dc.identifier.scopusquality Q3
dc.identifier.uri https://doi.org/10.2217/fon-2022-1287
dc.identifier.uri https://hdl.handle.net/20.500.14720/10409
dc.identifier.wos WOS:000991646700001
dc.identifier.wosquality Q3
dc.language.iso en en_US
dc.publisher Future Medicine Ltd en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Cdk 4 en_US
dc.subject 6 Inhibitors en_US
dc.subject Her2-Negative Metastatic Breast Cancer en_US
dc.subject Hr-Positive en_US
dc.subject Letrozole en_US
dc.title Treatment Efficacy of Ribociclib or Palbociclib Plus Letrozole in Hormone Receptor-positive/Her2-negative Metastatic Breast Cancer en_US
dc.type Article en_US

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