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Inhibition Properties of Some Flavonoids on Carbonic Anhydrase I and Ii Isoenzymes Purified From Human Erythrocytes

dc.authorscopusid 55394375700
dc.authorscopusid 6603903192
dc.authorscopusid 35509141500
dc.authorwosid Gulcin, Ilhami/F-1428-2014
dc.contributor.author Huyut, Zubeyir
dc.contributor.author Beydemir, Sukru
dc.contributor.author Gulcin, Ilhami
dc.date.accessioned 2025-05-10T17:07:40Z
dc.date.available 2025-05-10T17:07:40Z
dc.date.issued 2017
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Huyut, Zubeyir] Yuzuncu Yil Univ, Med Fac, Dept Biochem, Van, Turkey; [Beydemir, Sukru] Anadolu Univ, Dept Biochem, Fac Pharm, Eskisehir, Turkey; [Gulcin, Ilhami] Ataturk Univ, Dept Chem, Fac Sci, Erzurum, Turkey en_US
dc.description.abstract Carbonic anhydrases (CAs, E.C.4.2.1.1) play a critical role in many important physiological events and treatment of some diseases. Flavonoids or phenolic compounds have been discovered as novel CAs inhibitors instead of the traditional sulfonamides, with different binding to CAs, pro-drug activities, and new inhibition mechanisms. Here, we investigated the inhibition effects of some flavonoids including malvin, callistephin, oenin, pelargonin, silychristin, and 1-(4-methoxyphenyl)-2-methyl-3-nitro-1-H-indol-6-ol (ID-8) against hCA I and II, which purified from human erythrocytes by affinity column chromatography. Both hCA isoenzymes were inhibited by flavonoids, with IC50 and K-i values in the range of 2.34nM to 346.5M and 51.01-99.55M for hCA I and 86.60-750.00M for hCA II, respectively. These results showed that flavonoids especially malvin and oenin effectively inhibited hCA I and II isoenzymes. Hence, they may be used as an effective CA inhibitor in medical applications for treatment of certain diseases such as glaucoma, in the future. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.1002/jbt.21930
dc.identifier.issn 1095-6670
dc.identifier.issn 1099-0461
dc.identifier.issue 9 en_US
dc.identifier.pmid 28445001
dc.identifier.scopus 2-s2.0-85018369672
dc.identifier.scopusquality Q3
dc.identifier.uri https://doi.org/10.1002/jbt.21930
dc.identifier.uri https://hdl.handle.net/20.500.14720/6828
dc.identifier.volume 31 en_US
dc.identifier.wos WOS:000408915800005
dc.identifier.wosquality Q2
dc.language.iso en en_US
dc.publisher Wiley en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Antioxidants en_US
dc.subject Carbonic Anhydrase en_US
dc.subject Enzyme Inhibition en_US
dc.subject Flavonoid en_US
dc.subject Rbc en_US
dc.title Inhibition Properties of Some Flavonoids on Carbonic Anhydrase I and Ii Isoenzymes Purified From Human Erythrocytes en_US
dc.type Article en_US

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