YYÜ GCRIS Basic veritabanının içerik oluşturulması ve kurulumu Research Ecosystems (https://www.researchecosystems.com) tarafından devam etmektedir. Bu süreçte gördüğünüz verilerde eksikler olabilir.
 

Boswellic Acid and Betulinic Acid Pre-Treatments Can Prevent the Nephrotoxicity Caused by Cyclophosphamide Induction

dc.authorscopusid 12801030200
dc.authorscopusid 59130775000
dc.contributor.author Berkoz, Mehmet
dc.contributor.author Ciftci, Oguzhan
dc.date.accessioned 2025-05-10T17:23:01Z
dc.date.available 2025-05-10T17:23:01Z
dc.date.issued 2024
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Berkoz, Mehmet; Ciftci, Oguzhan] Van Yuzuncu Yil Univ, Fac Pharm, Dept Biochem, Van, Turkiye en_US
dc.description.abstract Cyclophosphamide (CYP) is a chemotherapeutic drug used to treat various cancers. However, its clinical use is limited due to severe organ damage, particularly to the kidneys. While several phytochemicals have been identified as potential therapeutic targets for CYP nephrotoxicity, the nephroprotective effects of boswellic acid (BOSW) and betulinic acid (BET) have not yet been investigated. Our study used 42 rats divided into six equal groups. The study included six groups: control, CYP (200 mg/kg), CYP+BOSW20 (20 mg/kg), CYP+BOSW40 (40 mg/kg), CYP+BET20 (20 mg/kg), and CYP+BET40 (40 mg/kg). The pre-treatments with BOSW and BET lasted for 14 days, while the application of cyclophosphamide was performed intraperitoneally only on the 4th day of the study. After the experimental protocol, the animals were sacrificed, and their kidney tissues were isolated. Renal function parameters, histological examination, oxidative stress, and inflammation parameters were assessed both biochemically and at the molecular level in kidney tissue. The results showed that oxidative stress and inflammatory response were increased in the kidney tissue of rats treated with CYP, leading to impaired renal histology and function parameters (p < 0.05). Oral administration of both doses of BET and especially high doses of BOSW improved biochemical, oxidative, and inflammatory parameters significantly (p < 0.05). Histological studies also showed the restoration of normal kidney tissue architecture. BOSW and BET have promising biological activity against CYP-induced nephrotoxicity by attenuating inflammation and oxidative stress and enhancing antioxidant status. en_US
dc.description.sponsorship Office of Scientific Research Projects of Van Yuzuncu Yil University [TYL-2021-9077] en_US
dc.description.sponsorship This research was financially supported by the Office of Scientific Research Projects of Van Yuzuncu Yil University under grant no. TYL-2021-9077. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.1134/S1607672924600234
dc.identifier.endpage 126 en_US
dc.identifier.issn 1607-6729
dc.identifier.issn 1608-3091
dc.identifier.issue 1 en_US
dc.identifier.pmid 38744737
dc.identifier.scopus 2-s2.0-85193353295
dc.identifier.scopusquality Q4
dc.identifier.startpage 115 en_US
dc.identifier.uri https://doi.org/10.1134/S1607672924600234
dc.identifier.uri https://hdl.handle.net/20.500.14720/10762
dc.identifier.volume 517 en_US
dc.identifier.wos WOS:001222574500003
dc.identifier.wosquality Q4
dc.language.iso en en_US
dc.publisher Maik Nauka/interperiodica/springer en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Cyclophosphamide en_US
dc.subject Nephrotoxicity en_US
dc.subject Boswellic Acid en_US
dc.subject Betulinic Acid en_US
dc.subject Oxidative Stress en_US
dc.subject Inflammation en_US
dc.title Boswellic Acid and Betulinic Acid Pre-Treatments Can Prevent the Nephrotoxicity Caused by Cyclophosphamide Induction en_US
dc.type Article en_US

Files