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Amniotic Fluid Oxidant-Antioxidant Status in Foetal Congenital Nervous System Anomalies

dc.authorid Tolunay, Harun Egemen/0000-0002-8922-4400
dc.authorid Boza, Baris/0000-0002-3831-3745
dc.authorid Cim, Numan/0000-0003-0983-3204
dc.authorscopusid 35955724600
dc.authorscopusid 55354165200
dc.authorscopusid 42262158200
dc.authorscopusid 57021916100
dc.authorscopusid 6603833662
dc.authorscopusid 55818321300
dc.authorscopusid 24462873600
dc.authorwosid Yildizhan, Recep/Aaa-8400-2021
dc.authorwosid Boza, Barış/Jxl-9400-2024
dc.authorwosid Karaman, Erbil/Afu-7129-2022
dc.authorwosid Tolunay, Harun/Aag-4620-2020
dc.authorwosid Cim, Numan/A-4305-2016
dc.contributor.author Cim, Numan
dc.contributor.author Tolunay, Harun Egemen
dc.contributor.author Karaman, Erbil
dc.contributor.author Boza, Baris
dc.contributor.author Bilici, Mustafa
dc.contributor.author Cetin, Orkun
dc.contributor.author Sahin, Hanim Guler
dc.date.accessioned 2025-05-10T17:04:52Z
dc.date.available 2025-05-10T17:04:52Z
dc.date.issued 2018
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Cim, Numan; Tolunay, Harun Egemen; Karaman, Erbil; Boza, Baris; Cetin, Orkun; Yildizhan, Recep; Sahin, Hanim Guler] Yuzuncu Yil Univ, Dept Obstet & Gynecol, Fac Med, Van, Turkey; [Bilici, Mustafa] Yuzuncu Yil Univ, Dept Biochem, Van Secur Collage, Van, Turkey en_US
dc.description Tolunay, Harun Egemen/0000-0002-8922-4400; Boza, Baris/0000-0002-3831-3745; Cim, Numan/0000-0003-0983-3204 en_US
dc.description.abstract Objective This study aimed to evaluate the oxidant-antioxidant status of amniotic fluid in pregnant women with foetal congenital malformations of the central nervous system. Methods We studied pregnant women with foetal congenital nervous system anomalies at 16-22 weeks' gestation (n=36). The control group (n=30) consisted of pregnant women at the same gestational age who underwent amniocentesis, resulting in a normal karyotype. We analysed glutathione, catalase, and malondialdehyde levels in amniotic fluid. Enzyme activation was measured by spectrophotometry. Results The demographic features of the groups were similar in terms of age, parity, body mass index, and gestational weeks. We detected lower glutathione and catalase levels in the foetal congenital anomaly group than in the control group. We detected higher malondialdehyde levels in the foetal congenital anomaly group than in the control group. Conclusion In the organism, the rate of formation of free radicals and their rate of removal are balanced, and this is called oxidative balance. As long as oxidative stability is achieved, the organism is not affected by free radicals. This fact should be kept in mind to avoid any type of teratogenic agent that could lead to congenital disorders. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.1177/0300060517734443
dc.identifier.endpage 1152 en_US
dc.identifier.issn 0300-0605
dc.identifier.issn 1473-2300
dc.identifier.issue 3 en_US
dc.identifier.pmid 29210307
dc.identifier.scopus 2-s2.0-85043372394
dc.identifier.scopusquality Q4
dc.identifier.startpage 1146 en_US
dc.identifier.uri https://doi.org/10.1177/0300060517734443
dc.identifier.uri https://hdl.handle.net/20.500.14720/6139
dc.identifier.volume 46 en_US
dc.identifier.wos WOS:000429877100023
dc.identifier.wosquality Q4
dc.language.iso en en_US
dc.publisher Sage Publications Ltd en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Amniotic Fluid en_US
dc.subject Foetal Congenital Nervous System Anomalies en_US
dc.subject Oxidant Status en_US
dc.subject Antioxidant en_US
dc.subject Pregnancy en_US
dc.subject Oxygen Free Radicals en_US
dc.title Amniotic Fluid Oxidant-Antioxidant Status in Foetal Congenital Nervous System Anomalies en_US
dc.type Article en_US

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