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Anom Approach for Statistical Evaluation of Some Antioxidant Enzyme Activities

dc.authorid Demir, Canan/0000-0002-4204-9756
dc.authorscopusid 57197170055
dc.authorscopusid 13005120600
dc.authorscopusid 8449363400
dc.authorwosid Şen, Fatih/O-9407-2016
dc.authorwosid Demir, Canan/Gwm-8855-2022
dc.contributor.author Demir, Canan
dc.contributor.author Keskin, Siddik
dc.contributor.author Sen, Fatih
dc.date.accessioned 2025-05-10T17:36:59Z
dc.date.available 2025-05-10T17:36:59Z
dc.date.issued 2022
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Demir, Canan; Keskin, Siddik] Van Yuzuncu Yil Univ, Fac Med, Dept Biostat Zeve Campus, Van, Turkey; [Sen, Fatih] Dumlupinar Univ, Fac Arts & Sci, Dept Biochem, Kutahya, Turkey en_US
dc.description Demir, Canan/0000-0002-4204-9756 en_US
dc.description.abstract Free radicals are chemical molecules that are more reactive and have an unpaired electron. Free radicals formed inside the cell oxidize biomolecules, leading to cell death and tissue damage. Antioxidants are molecules that can stabilize or inactivate free radicals before they damage the cell. In this study; the availability of Malondialdehyde, Superoxide dismutase, Catalase and Reduced glutathione levels as markers for related diseases was evaluated by examining whether and in what range they may vary in some diseases. In study, nine groups consist of prostate cancer, cirrhosis, liver transplantation, chronic kidney damage, acute kidney injury, X-ray exposure, CT exposure, MR exposure and Osteonecrosis. Analysis of means is a method developed to compare group means with the overall mean and presents the results graphically in an easy-to-understand manner without the required for any post hoc test. In addition, related characteristics were categorized as "low and high" and Nonlinear Principal Component Analysis was conducted to visually present their relationship with related disease types in two-dimensional space. The upper and lower decision lines were found 3.123 and 2.794 mu mol/L, respectively for Malondialdehyde. Those with cirrhosis, chronic kidney disease, acute kidney disease and tomography exposure were included in the upper and lower decision lines. Those with prostate cancer, osteonecrosis, and X-ray exposure were above the upper decision line and are found higher than the overall mean. Those with lung transplantation and MR exposure appear to be below the lower decision line and lower than the overall mean. The present study provides the first comprehensive assessment of the availability of Malondialdehyde, Superoxide dismutase, Catalase and Reduced glutathione levels as markers for some related diseases. This study has shown that Analysis of means can be used as an alternative graphical procedure for multiple group comparisons with an overall mean in the studies regarding as biochemical characteristics and relating diseases. In addition, Nonlinear Principal Component Analysis can be useful aid for decision marker in some biochemical characteristics and related diseases. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.3389/fchem.2022.894547
dc.identifier.issn 2296-2646
dc.identifier.pmid 35720997
dc.identifier.scopus 2-s2.0-85132922381
dc.identifier.scopusquality Q1
dc.identifier.uri https://doi.org/10.3389/fchem.2022.894547
dc.identifier.uri https://hdl.handle.net/20.500.14720/14220
dc.identifier.volume 10 en_US
dc.identifier.wos WOS:000812869100001
dc.identifier.wosquality Q2
dc.language.iso en en_US
dc.publisher Frontiers Media Sa en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Anom en_US
dc.subject Free Radicals en_US
dc.subject Mda en_US
dc.subject Nlpca en_US
dc.subject Oxidative Stress en_US
dc.title Anom Approach for Statistical Evaluation of Some Antioxidant Enzyme Activities en_US
dc.type Article en_US

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