Effects of Leontice Leontopetalum and Bongardia Chrysogonum on Oxidative Stress and Neuroprotection in Ptz Kindling Epilepsy in Rats
| dc.authorid | Karatas, Ersin/0000-0001-6848-7618 | |
| dc.authorid | Ozgokce, Fevzi/0000-0002-3119-8561 | |
| dc.authorid | Mukemre, Muzaffer/0000-0001-6154-6603 | |
| dc.authorid | Erten, Remzi/0000-0001-7775-5792 | |
| dc.authorscopusid | 57193334079 | |
| dc.authorscopusid | 16174494200 | |
| dc.authorscopusid | 7006159432 | |
| dc.authorscopusid | 57191405409 | |
| dc.authorscopusid | 24461417500 | |
| dc.authorscopusid | 56259656000 | |
| dc.authorscopusid | 55624671000 | |
| dc.authorwosid | Erkec, Ozlem/A-2042-2017 | |
| dc.authorwosid | Erten, Remzi/V-5175-2019 | |
| dc.authorwosid | Meral, Ismail/O-7139-2019 | |
| dc.authorwosid | Mukemre, Muzaffer/Mtd-6466-2025 | |
| dc.authorwosid | Karatas, Ersin/G-1852-2016 | |
| dc.authorwosid | Ozgokce, Fevzi/V-2091-2019 | |
| dc.contributor.author | Erkec, Ozlem Ergul | |
| dc.contributor.author | Arihan, Okan | |
| dc.contributor.author | Kara, Mehmet | |
| dc.contributor.author | Karatas, Ersin | |
| dc.contributor.author | Erten, Remzi | |
| dc.contributor.author | Demir, Halit | |
| dc.contributor.author | Ozgokce, Fevzi | |
| dc.date.accessioned | 2025-05-10T17:11:00Z | |
| dc.date.available | 2025-05-10T17:11:00Z | |
| dc.date.issued | 2018 | |
| dc.department | T.C. Van Yüzüncü Yıl Üniversitesi | en_US |
| dc.department-temp | [Erkec, Ozlem Ergul; Arihan, Okan; Kara, Mehmet] Van Yuzuncu Yil Univ, Fac Med, Dept Physiol, Van, Turkey; [Karatas, Ersin] Bezmialem Vakif Univ, Fac Med, Dept Med Biochem, Istanbul, Turkey; [Erten, Remzi] Van Yuzuncu Yil Univ, Fac Med, Dept Pathol, Van, Turkey; [Demir, Halit] Van Yuzuncu Yil Univ, Fac Sci, Dept Chem, Van, Turkey; [Meral, Ismail] Bezmialem Vakif Univ, Fac Med, Dept Physiol, Istanbul, Turkey; [Mukemre, Muzaffer; Ozgokce, Fevzi] Van Yuzuncu Yil Univ, Fac Sci, Dept Biol, Van, Turkey | en_US |
| dc.description | Karatas, Ersin/0000-0001-6848-7618; Ozgokce, Fevzi/0000-0002-3119-8561; Mukemre, Muzaffer/0000-0001-6154-6603; Erten, Remzi/0000-0001-7775-5792 | en_US |
| dc.description.abstract | We investigated the effects of Leontice leontopetalum and Bongardia chrysogonum on apoptosis, gamma-aminobutyric acid (GABA(A)) receptor positive cell number. cyclin-B1 and bcl-2 levels and oxidative stress in pentylenetetrazol (PTZ.) kindling in rats. Kindling was produced by subconvulsant doses of PTZ treatments in rats. Wistar albino rats were divided into 4 groups; Control, PTZ treated (PTZ), PTZ ;L. leontopetalum extract treated (PTZ FILE) and PTZ ;B. chrysogonum extract treated (PTZ+BCE) groups. Extracts were given a dose (200 mg/kg) 2h before each PTZ, injection. PTZ treatment significantly decreased the glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) activities and bc1-2 levels and increased the total oxidant status (TOS), malondialdehyde (MDA), cyclin B1, oxidative stress index (OSI) and number of neurons that expressed GABA(A) receptors when compared to the control. LLE and BCE possessed antioxidant activity in the brain and ameliorated PTZ induced oxidative stress, decreased cyclin-B1, increased bcl-2 levels, and kept the GABA(A) receptor number similar to that of the control despite the PTZ application. | en_US |
| dc.description.sponsorship | Research Fund of the Van Yuzuncu Yil University [2015-TFB-129] | en_US |
| dc.description.sponsorship | This work was supported by Research Fund of the Van Yuzuncu Yil University (Project number: 2015-TFB-129). The authors gratefully acknowledge the support of the Huseyin Eroglu from Van Yuzuncu Yil University, Department of Biology for his collection and identification of Bongardia chrysogonum. The authors are grateful to Prof. Dr Siddik Keskin for the statistical analysis. | en_US |
| dc.description.woscitationindex | Science Citation Index Expanded | |
| dc.identifier.doi | 10.14715/cmb/2017.64.15.12 | |
| dc.identifier.endpage | 77 | en_US |
| dc.identifier.issn | 0145-5680 | |
| dc.identifier.issn | 1165-158X | |
| dc.identifier.issue | 15 | en_US |
| dc.identifier.pmid | 30672439 | |
| dc.identifier.scopus | 2-s2.0-85060402842 | |
| dc.identifier.scopusquality | Q4 | |
| dc.identifier.startpage | 71 | en_US |
| dc.identifier.uri | https://doi.org/10.14715/cmb/2017.64.15.12 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14720/7608 | |
| dc.identifier.volume | 64 | en_US |
| dc.identifier.wos | WOS:000457568300012 | |
| dc.identifier.wosquality | Q4 | |
| dc.language.iso | en | en_US |
| dc.publisher | C M B Assoc | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Bcl-2 | en_US |
| dc.subject | Brain | en_US |
| dc.subject | Bongardia Chrysogonum | en_US |
| dc.subject | Cyclin-B1 | en_US |
| dc.subject | Gaba(A) | en_US |
| dc.subject | Kindling Model | en_US |
| dc.subject | Leontice Leontopetalum | en_US |
| dc.subject | Oxidative Stress | en_US |
| dc.subject | Pentylenetetrazol | en_US |
| dc.title | Effects of Leontice Leontopetalum and Bongardia Chrysogonum on Oxidative Stress and Neuroprotection in Ptz Kindling Epilepsy in Rats | en_US |
| dc.type | Article | en_US |