Effects of Zinc Supplementation on Dna Damage in Rats With Experimental Kidney Deficiency
| dc.authorid | Dede, Semiha/0000-0001-5744-6327 | |
| dc.authorscopusid | 55762891900 | |
| dc.authorscopusid | 6603709171 | |
| dc.authorscopusid | 37040724900 | |
| dc.authorscopusid | 6603102677 | |
| dc.authorwosid | Mis, Leyla/Hhz-3202-2022 | |
| dc.authorwosid | Dede, Semiha/H-5403-2013 | |
| dc.contributor.author | Yegin, Sevim Ciftci | |
| dc.contributor.author | Dede, Semiha | |
| dc.contributor.author | Mis, Leyla | |
| dc.contributor.author | Yur, Fatmagul | |
| dc.date.accessioned | 2025-05-10T17:28:03Z | |
| dc.date.available | 2025-05-10T17:28:03Z | |
| dc.date.issued | 2017 | |
| dc.department | T.C. Van Yüzüncü Yıl Üniversitesi | en_US |
| dc.department-temp | [Yegin, Sevim Ciftci] Univ Giresun, Hlth Serv Vocat Sch Higher Educ, Giresun, Turkey; [Dede, Semiha] Yuzuncu Yil Univ, Dept Biochem, Fac Vet Sci, Van, Turkey; [Mis, Leyla] Yuzuncu Yil Univ, Dept Physiol, Fac Vet Sci, Van, Turkey; [Yur, Fatmagul] Univ Mugla Sitki Kocman, Dept Nutr & Dietet, Fethiye Sch Hlth, Mugla, Turkey | en_US |
| dc.description | Dede, Semiha/0000-0001-5744-6327 | en_US |
| dc.description.abstract | This study was carried out to determine the effect of zinc on oxidative DNA damage in rats with experimental acute and chronic kidney deficiency. Six groups of five Wistar-Albino rats each were assigned as controls (C), acute kidney deficiency (AKD), zinc-supplemented (+Zn), acute kidney deficiency, zinc-supplemented (AKD + Zn), chronic kidney deficiency (CKD) and zinc-supplemented chronic kidney deficiency (CKD + Zn). The levels of 8-Oxo-2'-deoxyguanosine (8-OHdG) were determined, being the lowest in the CKD group (p < 0.05), higher in the C group than those of rats with CKD but lower than that of all the other groups (p < 0.05). There were no significant differences between the controls and the CKD + Zn group, or between the AKD and the +Zn groups. Among all groups, the highest 8-OHdG level was found in the AKD + Zn group (p < 0.05). DNA damage was greater in acute renal failure than in rats with chronic renal failure. The DNA damage in the zinc group was significantly higher than in the controls. | en_US |
| dc.description.woscitationindex | Science Citation Index Expanded | |
| dc.identifier.doi | 10.1007/s12011-016-0826-9 | |
| dc.identifier.endpage | 341 | en_US |
| dc.identifier.issn | 0163-4984 | |
| dc.identifier.issn | 1559-0720 | |
| dc.identifier.issue | 2 | en_US |
| dc.identifier.pmid | 27612456 | |
| dc.identifier.scopus | 2-s2.0-84986243940 | |
| dc.identifier.scopusquality | Q1 | |
| dc.identifier.startpage | 338 | en_US |
| dc.identifier.uri | https://doi.org/10.1007/s12011-016-0826-9 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14720/11929 | |
| dc.identifier.volume | 176 | en_US |
| dc.identifier.wos | WOS:000396260000014 | |
| dc.identifier.wosquality | Q2 | |
| dc.language.iso | en | en_US |
| dc.publisher | Humana Press inc | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Dna Damage | en_US |
| dc.subject | Renal Impair | en_US |
| dc.subject | Zinc | en_US |
| dc.title | Effects of Zinc Supplementation on Dna Damage in Rats With Experimental Kidney Deficiency | en_US |
| dc.type | Article | en_US |