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Assessment of Cardiac Functions in Fetuses of Gestational Diabetic Mothers

dc.authorid Oflaz, Mehmet Burhan/0000-0003-1515-4654
dc.authorscopusid 35290695100
dc.authorscopusid 16231061200
dc.authorscopusid 36637236400
dc.authorscopusid 35290933200
dc.authorscopusid 16417157900
dc.authorscopusid 27171503000
dc.authorwosid Ballı, Sevket/Aak-7541-2021
dc.authorwosid Kandemir, Özlem/Kap-1812-2024
dc.authorwosid Oflaz, Mehmet Burhan/L-5566-2019
dc.contributor.author Balli, Sevket
dc.contributor.author Pac, Feyza Aysenur
dc.contributor.author Ece, Ibrahim
dc.contributor.author Oflaz, Mehmet Burhan
dc.contributor.author Kibar, Ayse Esin
dc.contributor.author Kandemir, Omer
dc.date.accessioned 2025-05-10T17:22:38Z
dc.date.available 2025-05-10T17:22:38Z
dc.date.issued 2014
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Balli, Sevket] Balikesir Ataturk Hosp, Dept Pediat Cardiol, Balikesir, Turkey; [Pac, Feyza Aysenur] Turkiye Yuksek Ihtisas Training & Educ Hosp, Dept Pediat Cardiol, Ankara, Turkey; [Ece, Ibrahim] Yuzuncu Yil Univ, Dept Pediat Cardiol, Fac Med, Van, Turkey; [Oflaz, Mehmet Burhan] Cumhuriyet Univ, Dept Pediat Cardiol, Fac Med, Sivas, Turkey; [Kibar, Ayse Esin] Mersin Childrens Hosp, Dept Pediat Cardiol, Mersin, Turkey; [Kandemir, Omer] Zubeyde Hanim Obstet & Childrens Hosp, Dept Obstet & Gynecol, Ankara, Turkey en_US
dc.description Oflaz, Mehmet Burhan/0000-0003-1515-4654 en_US
dc.description.abstract We investigated cardiac function in 67 fetuses of gestational diabetic mothers (FGDMs) and 122 fetuses of healthy mothers between 24 and 36 weeks of gestation. Cardiac functions were evaluated by M-mode, pulsed-wave, and tissue Doppler echocardiography. Fetal echocardiograms were performed at 24, 28, 32, and 36 weeks of gestation. Glycated hemoglobin (HbA1c) levels were obtained from all pregnant women at 24 weeks of gestation. The mean age of diabetic pregnant women was significantly greater than that of controls. Serum HbA1c values of both groups were within normal limits, but they were significantly greater in the diabetic group (p = 0.003). The increase in peak aortic and pulmonary artery velocities were greater in FGDM (p < 0.001). No pathological interventricular septal (IVS) hypertrophy was observed. There was a significant increase in IVS thickness in FGDM compared with controls, which was more prominent at the end of the third trimester (p < 0.001). During the course of pregnancy, mitral E-wave (p < 0.001), A-wave (p = 0.007), tricuspid E-wave (p < 0.001) and A-wave (p = 0.002) velocities were greater in FGDM. The increases in mitral E/A and tricuspid E/A ratios were lower in FGDM with advancing gestation. The E (a)-wave (p = 0.02), A (a)-wave (p = 0.04), and S (a)-wave (p < 0.001) velocities of the right-ventricular (RV) free wall and the E (a) (p = 0.02) and A (a) (p = 0.01) velocities of the left-ventricle (LV) posterior wall were greater in FGDM during the course of pregnancy. The E (a)/A (a) ratio of the RV posterior wall was greater in FGDM with advancing gestation (p < 0.03). LV and RV E/E (a) ratios were similar in both groups. The LV myocardial performance index measured by pulsed-wave Doppler was greater in FGDM (p < 0.001). We detected diastolic dysfunction in FGDM. The data suggest that gestational diabetes mellitus may impair ventricular diastolic functions without causing pathological fetal myocardial hypertrophy. We detected subclinical diastolic dysfunction using both pulsed-wave and tissue Doppler imaging in FGDM. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.1007/s00246-013-0734-0
dc.identifier.endpage 37 en_US
dc.identifier.issn 0172-0643
dc.identifier.issn 1432-1971
dc.identifier.issue 1 en_US
dc.identifier.pmid 23780554
dc.identifier.scopus 2-s2.0-84893684791
dc.identifier.scopusquality Q2
dc.identifier.startpage 30 en_US
dc.identifier.uri https://doi.org/10.1007/s00246-013-0734-0
dc.identifier.uri https://hdl.handle.net/20.500.14720/10624
dc.identifier.volume 35 en_US
dc.identifier.wos WOS:000329374800005
dc.identifier.wosquality Q3
dc.language.iso en en_US
dc.publisher Springer en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Gestational Diabetes Mellitus en_US
dc.subject Cardiac Function en_US
dc.subject Fetal Echocardiography en_US
dc.title Assessment of Cardiac Functions in Fetuses of Gestational Diabetic Mothers en_US
dc.type Article en_US

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