The Antioxidant Role of Sideritis Caesarea Infusion Against Tca Toxicity in Rats
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Date
2011
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Journal Title
Journal ISSN
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Publisher
Cambridge Univ Press
Abstract
Sideritis caesarea (SC) Duman, Aytac&Baser is a member of the Lamiaceae family. The present study was designed to investigate the antioxidant properties of the aerial parts of island green tea SC against TCA effects in rats. Biomarkers selected for monitoring antioxidant capacity were the activities of glutathione reductase (GR), superoxide dismutase (SOD), glutathione-S-transferase, catalase (CAT), GSH level and malondialdehyde (MDA) content in various organs of rats. Three experimental groups, A (untreated - control), B (only TCA-treated) and C (TCA + SC-treated), were studied. At the end of the 50 d experiment, the MDA content in tissues increased significantly in group B, whereas no significant changes were observed in group C as compared with that of the control group. Antioxidant enzyme activities such as SOD and CAT increased significantly in the brain, liver and kidneys of group B but decreased significantly in group C as compared with group B. The GSH level and GR activity increased significantly in the brain and liver of group C as compared with the control and TCA-exposed rats. Hence, the study reveals that the constituents present in SC impart protection against chemical-induced oxidative injury that may result in the development of cancer.
Description
Keywords
Sideritis Caesarea (Lamiaceae), Medicinal Food, Tca, Antioxidant Defence Systems, Malondialdehyde, Rats
Turkish CoHE Thesis Center URL
WoS Q
Q3
Scopus Q
Q2
Source
Volume
105
Issue
5
Start Page
663
End Page
668