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Determination of Mic Values of Various Antimicrobial Agents and Presence of Resistance Genes in Pasteurella Multocida Strains Isolated From Bovine

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Date

2021

Journal Title

Journal ISSN

Volume Title

Publisher

Kafkas Univ, veteriner Fakultesi dergisi

Abstract

Pasteurella multocida is an important bacterium that can cause respiratory infections in cattle. Due to the usage of antimicrobial agents in the treatment of the disease frequently, it is critical to follow the antimicrobial susceptibility of the isolates. In this study, minimal inhibitory concentrations (MIC) of various antimicrobial agents and presence of genes related to resistance were investigated in 59 P. multocida strains isolated from the respiratory tract of cattle. According to MIC values determined by E-test, all of the isolates were susceptible to enrofloxacin, chloramphenicol and gentamicin, but resistant to cefoxitin. In addition, high resistance to ampicillin (88.14%), tilmicosin (64.41%), clindamycin (83.05%) and streptomycin (59.32%) were observed in the isolates. When the resistance genes were examined by PCR, it was determined that blaROB-1, tet H, sul II, str A/aphA 1 and erm 42 genes could play an important role in penicillin, tetracycline, sulfamethoxazole + trimethoprime, aminoglycoside and macrolide resistance, respectively. It was concluded that the usage of ampicillin, tetracycline, sulfamethoxazole + trimethoprime, macrolide and aminoglycosides should be considered for the treatment of respiratory tract infections caused by P. multocida in cattle. Also, it was determined that antimicrobial resistance genes could play an important role in the development of resistance in P. multocida.

Description

Ekin, Ismail Hakki/0000-0001-5029-8130

Keywords

Pasteurella Multocida, Antimicrobial Susceptibility, Mic, Resistance Gene

Turkish CoHE Thesis Center URL

WoS Q

Q3

Scopus Q

Q3

Source

Volume

27

Issue

2

Start Page

217

End Page

224