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Investigation of Inhibition Effect of Butanol and Water Extracts of Matricaria Chamomilla L. on Angiotensin-Converting Enzyme Purified From Human Plasma

dc.authorid Bas, Zehra/0000-0002-4071-9744
dc.authorscopusid 57221676721
dc.authorscopusid 55925236900
dc.authorscopusid 56095551600
dc.contributor.author Bas, Zehra
dc.contributor.author Turkoglu, Vedat
dc.contributor.author Goz, Yasar
dc.date.accessioned 2025-05-10T17:10:34Z
dc.date.available 2025-05-10T17:10:34Z
dc.date.issued 2022
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Bas, Zehra; Goz, Yasar] Van Yuzuncu Yil Univ, Dept Nutr & Dietet, Fac Hlth Sci, TR-65080 Van, Turkey; [Turkoglu, Vedat] Van Yuzuncu Yil Univ, Dept Chem, Fac Sci, Van, Turkey en_US
dc.description Bas, Zehra/0000-0002-4071-9744 en_US
dc.description.abstract Angiotensin-converting enzyme (ACE) liable for the regulation of blood pressure was purified from human plasma by affinity chromatography. Impact of water and butanol extracts of Matricaria chamomilla L. on purity ACE was examined. ACE was purified using the affinity chromatography method. The enzyme activity was evaluated at 345 nm by a . Extracts of M. chamomilla plant with butanol and water were prepared. Lisinopril was utilized as a specific inhibitor. ACE was purified 3,659-fold from human plasma and the specific activity was 1,350 EU/mg protein. The molecular weight and purity of ACE were found by SDS-PAGE and two bands of 60 and 70 kDa on the gel were detected. Water and butanol extracts of M. chamomilla demonstrated inhibitor impact on ACE activity. IC50 constants for water and butanol extracts of M. chamomilla were computed to be 1.292 and 0.353 mg/mL, respectively. The type of inhibition for whole inhibitors was identified as noncompetitive. IC50 and K-i constants for lisinopril were calculated to be 0.781 and 0.662 nM, respectively. These results indicate that butanol and water extracts of M. chamomilla may have an ACE inhibitor potential. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.1002/bab.2106
dc.identifier.endpage 280 en_US
dc.identifier.issn 0885-4513
dc.identifier.issn 1470-8744
dc.identifier.issue 1 en_US
dc.identifier.pmid 33438805
dc.identifier.scopus 2-s2.0-85099741009
dc.identifier.scopusquality Q3
dc.identifier.startpage 273 en_US
dc.identifier.uri https://doi.org/10.1002/bab.2106
dc.identifier.uri https://hdl.handle.net/20.500.14720/7474
dc.identifier.volume 69 en_US
dc.identifier.wos WOS:000611043800001
dc.identifier.wosquality Q3
dc.language.iso en en_US
dc.publisher Wiley en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Angiotensin-Converting Enzyme en_US
dc.subject Inhibiton en_US
dc.subject Matricaria Chamomilla L. en_US
dc.title Investigation of Inhibition Effect of Butanol and Water Extracts of Matricaria Chamomilla L. on Angiotensin-Converting Enzyme Purified From Human Plasma en_US
dc.type Article en_US

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