Effect of Metformin/Irinotecan-loaded Poly-Lactic Acid Nanoparticles on Glioblastoma: in Vitro and in Vivo Studies
| dc.authorid | Hacimuftuoglu, Ahmet/0000-0002-9658-3313 | |
| dc.authorid | Abd El-Aty, A. M./0000-0001-6596-7907 | |
| dc.authorid | Stivaktakis, Polychronis/0000-0001-6004-2948 | |
| dc.authorid | Nalci, Kemal Alp/0000-0003-3786-5246 | |
| dc.authorid | Tsatsakis, Aristidis/0000-0003-3824-2462 | |
| dc.authorscopusid | 56444330700 | |
| dc.authorscopusid | 6602395368 | |
| dc.authorscopusid | 36088991000 | |
| dc.authorscopusid | 57203146871 | |
| dc.authorscopusid | 35388271400 | |
| dc.authorscopusid | 57214030248 | |
| dc.authorscopusid | 7402046023 | |
| dc.authorwosid | Okkay, Ufuk/Abc-2672-2021 | |
| dc.authorwosid | Mezhuev, Yaroslav/F-8596-2017 | |
| dc.authorwosid | Ghaffari, Mohammad/B-7840-2019 | |
| dc.authorwosid | Çetin, Meltem/Abi-4879-2020 | |
| dc.authorwosid | Ugur Kaplan, Afife Busra/Aay-2218-2021 | |
| dc.authorwosid | Taşpinar, Mehmet/Lig-3987-2024 | |
| dc.authorwosid | Tsatsakis, Aristidis/H-2890-2013 | |
| dc.contributor.author | Taghizadehghalehjoughi, Ali | |
| dc.contributor.author | Hacimuftuoglu, Ahmet | |
| dc.contributor.author | Cetin, Meltem | |
| dc.contributor.author | Ugur, Afife Busra | |
| dc.contributor.author | Galateanu, Bianca | |
| dc.contributor.author | Mezhuev, Yaroslav | |
| dc.contributor.author | Abd El-Aty, A. M. | |
| dc.date.accessioned | 2025-05-10T17:05:06Z | |
| dc.date.available | 2025-05-10T17:05:06Z | |
| dc.date.issued | 2018 | |
| dc.department | T.C. Van Yüzüncü Yıl Üniversitesi | en_US |
| dc.department-temp | [Taghizadehghalehjoughi, Ali] Ataturk Univ, Dept Pharmacol & Toxicol, Fac Vet Sci, TR-25240 Erzurum, Turkey; [Hacimuftuoglu, Ahmet; Okkay, Ufuk; Taspinar, Numan; Mohammadzadeh, Maryam; Nalci, Kemal Alp; Abd El-Aty, A. M.] Ataturk Univ, Dept Med Pharmacol, Fac Med, TR-25240 Erzurum, Turkey; [Cetin, Meltem; Ugur, Afife Busra] Ataturk Univ, Dept Pharmaceut Technol, Fac Pharm, TR-25240 Erzurum, Turkey; [Galateanu, Bianca] Dept Biochem & Mol Biol, 91-95 Splaiul Independentei,Dist 5, Bucharest 050095, Romania; [Mezhuev, Yaroslav] D Mendeleev Univ Chem Technol Russia, Ctr Biomat, Miusskaya Sq 9, Moscow 125047, Russia; [Taspinar, Mehmet] Yuzuncu Yil Univ, Sch Med, Dept Med Biol, Van, Turkey; [Uyanik, Abdullah] Ataturk Univ, Dept Nephrol, Fac Med, TR-25240 Erzurum, Turkey; [Gundogdu, Betul] Ataturk Univ, Dept Pathol, Fac Med, TR-25240 Erzurum, Turkey; [Stivaktakis, Polychronis; Tsatsakis, Aristidis] Univ Crete, Toxicol Lab, Sch Med, Iraklion 71003, Greece; [Stivaktakis, Polychronis; Tsatsakis, Aristidis] Univ Crete Spin Off, Toxplus SA, Iraklion 71601, Greece; [Jung, Tae Woo] Seoul Natl Univ, Res Adm Team, Bundang Hosp, Gyeonggi, South Korea; [Jeong, Ji Hoon] Chung Ang Univ, Dept Pharmacol, Coll Med, Seoul, South Korea; [Abd El-Aty, A. M.] Cairo Univ, Dept Pharmacol, Fac Vet Med, Giza 12211, Egypt | en_US |
| dc.description | Hacimuftuoglu, Ahmet/0000-0002-9658-3313; Abd El-Aty, A. M./0000-0001-6596-7907; Stivaktakis, Polychronis/0000-0001-6004-2948; Nalci, Kemal Alp/0000-0003-3786-5246; Tsatsakis, Aristidis/0000-0003-3824-2462 | en_US |
| dc.description.abstract | Aim: The present study was designed to evaluate the effects of irinotecan hydrochloride (IRI)- or metformin hydrochloride (MET)-loaded poly-lactic-co-glycolic acid (PLGA) nanoparticles (NPs) for the treatment of glioblastoma multiforme using in vitro neuron and U-87 MG glioblastoma cell cultures and in vivo animal model. Methods: The cytotoxic and neurotoxic effects of pure drugs, blank NPs and MET- and IRI-loaded PLGA NPs were investigated in vitro (using methylthiazolyldiphenyl-tetrazolium bromide assay) and in vivo (using Cavalieri's principle for estimation of cancer volume). Results: 1 and 2 mM doses of MET and MET-loaded PLGA NPs, respectively, significantly reduced the volume of extracted cancer. Conclusion: Consequently, MET- and IRI-loaded PLGA NPs may be a promising approach for the treatment of glioblastoma multiforme. | en_US |
| dc.description.sponsorship | Scientific and Technological Research Council of Turkey (TUBITAK) [113S083] | en_US |
| dc.description.sponsorship | This work was supported by the Scientific and Technological Research Council of Turkey (TUBITAK, Project Number: 113S083). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. | en_US |
| dc.description.woscitationindex | Science Citation Index Expanded | |
| dc.identifier.doi | 10.2217/nnm-2017-0386 | |
| dc.identifier.endpage | 1606 | en_US |
| dc.identifier.issn | 1743-5889 | |
| dc.identifier.issn | 1748-6963 | |
| dc.identifier.issue | 13 | en_US |
| dc.identifier.pmid | 30028222 | |
| dc.identifier.scopus | 2-s2.0-85050696817 | |
| dc.identifier.scopusquality | Q2 | |
| dc.identifier.startpage | 1595 | en_US |
| dc.identifier.uri | https://doi.org/10.2217/nnm-2017-0386 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14720/6212 | |
| dc.identifier.volume | 13 | en_US |
| dc.identifier.wos | WOS:000441781300007 | |
| dc.identifier.wosquality | Q1 | |
| dc.language.iso | en | en_US |
| dc.publisher | Future Medicine Ltd | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Brain Tumor | en_US |
| dc.subject | Cavalieri'S Principle | en_US |
| dc.subject | Irinotecan | en_US |
| dc.subject | Metformin | en_US |
| dc.subject | Nanoparticles | en_US |
| dc.subject | Plga | en_US |
| dc.title | Effect of Metformin/Irinotecan-loaded Poly-Lactic Acid Nanoparticles on Glioblastoma: in Vitro and in Vivo Studies | en_US |
| dc.type | Article | en_US |