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Evaluation of Meibomian Glands in Obstructive Sleep Apnea-Hypopnea Syndrome

dc.authorid Bozkurt, Erdinc/0000-0002-5570-799X
dc.authorid Erten, Remzi/0000-0001-7775-5792
dc.authorscopusid 55964654600
dc.authorscopusid 57216677059
dc.authorscopusid 24461417500
dc.authorscopusid 56650731100
dc.authorwosid Bozkurt, Erdinc/Aaf-9508-2021
dc.authorwosid Erten, Remzi/V-5175-2019
dc.contributor.author Muhafiz, Ersin
dc.contributor.author Olcen, Merhamet
dc.contributor.author Erten, Remzi
dc.contributor.author Bozkurt, Erdinc
dc.date.accessioned 2025-05-10T17:09:11Z
dc.date.available 2025-05-10T17:09:11Z
dc.date.issued 2020
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Muhafiz, Ersin; Bozkurt, Erdinc] Kafkas Univ, Dept Ophthalmol, Fac Med, Kars, Turkey; [Olcen, Merhamet] Sanliurfa Training & Res Hosp, Dept Chest Dis, Sanliurfa, Turkey; [Erten, Remzi] Van Yuzuncu Yil Univ, Dept Pathol, Fac Med, Van, Turkey en_US
dc.description Bozkurt, Erdinc/0000-0002-5570-799X; Erten, Remzi/0000-0001-7775-5792 en_US
dc.description.abstract Purpose: To evaluate the effect of obstructive sleep apnea-hypopnea syndrome (OSAHS) on the meibomian glands, ocular surface, and tear parameters. Methods: The study included 59 individuals (32 subjects with OSAHS, 27 control subjects) who underwent polysomnography in the Chest Diseases Clinic. The right eyes of all individuals were evaluated in the Ophthalmology Clinic. The first noninvasive tear break-up time (f-NTBUT) and the average noninvasive tear break-up time were measured, and Schirmer test was applied. Meibography was taken (Sirius; CSO, Florence, Italy), and meiboscore was used for indexing meibography. Finally, a sample was taken for conjunctival impression cytology. Results: In the study and control groups, the median of f-NTBUT was 2.1 seconds [interquartile range (IQR); 1.5-5.0] and 5.7 seconds (IQR; 2.9-8.8) and the median of average noninvasive tear break-up time was 5.6 seconds (IQR; 3.6-9.5) and 7.2 seconds (IQR; 4.2-10.7), respectively (P= 0.007 andP= 0.487, respectively). The mean Schirmer value was 16.3 +/- 5.9 mm (range; 5-25) and 17.3 +/- 6.6 mm (range; 5-30) in the study and control groups (P= 0.604). In upper eyelid meibography, the median of loss in the meibomian glands was 20.10% (IQR; 11.60%-40.80%) in the study group and 14.70% (IQR; 10.40%-21.30%) in the control group (P= 0.043). In lower eyelid meibography, the median of loss in the meibomian glands was 19.00% (IQR; 13.60%-35.30%) in the study group and 12.40% (IQR; 9.10%-16.40%) in the control group (P= 0.002). The median of the Nelson grade in conjunctival impression cytology was 1 (IQR; 0-1) in the study group and 1 (IQR; 0-1) in the control group (P= 0.445). Conclusions: The loss in the meibomian glands together with the shortened f-NTBUT shows that there could be a predisposition in OSAHS for evaporative dry eye originating from meibomian gland damage. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.1097/ICO.0000000000002252
dc.identifier.endpage 690 en_US
dc.identifier.issn 0277-3740
dc.identifier.issn 1536-4798
dc.identifier.issue 6 en_US
dc.identifier.pmid 31939920
dc.identifier.scopus 2-s2.0-85084271819
dc.identifier.scopusquality Q1
dc.identifier.startpage 685 en_US
dc.identifier.uri https://doi.org/10.1097/ICO.0000000000002252
dc.identifier.uri https://hdl.handle.net/20.500.14720/7074
dc.identifier.volume 39 en_US
dc.identifier.wos WOS:000571785000006
dc.identifier.wosquality Q2
dc.language.iso en en_US
dc.publisher Lippincott Williams & Wilkins en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Osahs en_US
dc.subject Meibomian Glands en_US
dc.subject Meibography en_US
dc.subject Tear Functions en_US
dc.subject Impression Cytology en_US
dc.title Evaluation of Meibomian Glands in Obstructive Sleep Apnea-Hypopnea Syndrome en_US
dc.type Article en_US

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