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Dual-Phase F-18 Fdg Pet-Ct in Staging and Lymphoscintigraphy for Detection of Sentinel Lymph Nodes in Oral Cavity Cancers

dc.authorid Ada, Emel/0000-0002-0463-0945
dc.authorid Demir, Yusuf/0000-0001-6762-1977
dc.authorid Sarioglu, Sulen/0000-0003-4877-3064
dc.authorscopusid 36195782500
dc.authorscopusid 56028782100
dc.authorscopusid 35745637500
dc.authorscopusid 56526937700
dc.authorscopusid 55375424200
dc.authorscopusid 7003736223
dc.authorscopusid 6603810790
dc.authorwosid Celik, Ahmet/Iap-5710-2023
dc.authorwosid Ada, Emel/Aac-3966-2020
dc.authorwosid Ada, Emel/Aar-7664-2020
dc.authorwosid Demir, Yusuf/L-2096-2013
dc.authorwosid Sarioglu, Sulen/F-4706-2011
dc.contributor.author Surucu, Erdem
dc.contributor.author Polack, Berna Degirmenci
dc.contributor.author Demir, Yusuf
dc.contributor.author Durmusoglu, Mehmet
dc.contributor.author Ekmekci, Sumeyye
dc.contributor.author Sarioglu, Alien
dc.contributor.author Ikiz, Ahmet Omer
dc.date.accessioned 2025-05-10T17:11:52Z
dc.date.available 2025-05-10T17:11:52Z
dc.date.issued 2015
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Surucu, Erdem; Demir, Yusuf] Yuzuncu Yil Univ, Sch Med, Dept Nucl Med, Van, Turkey; [Polack, Berna Degirmenci] Dokuz Eylul Univ, Sch Med, Dept Nucl Med, Izmir, Turkey; [Durmusoglu, Mehmet; Ikiz, Ahmet Omer] Dokuz Eylul Univ, Sch Med, Dept Ear Eose Throat & Head & Neck Surg, Izmir, Turkey; [Ekmekci, Sumeyye; Sarioglu, Alien] Dokuz Eylul Univ, Sch Med, Dept Pathol, Izmir, Turkey; [Celik, Ahmet Orhan; Ada, Emel] Dokuz Eylul Univ, Sch Med, Dept Radiol, Izmir, Turkey en_US
dc.description Ada, Emel/0000-0002-0463-0945; Demir, Yusuf/0000-0001-6762-1977; Sarioglu, Sulen/0000-0003-4877-3064 en_US
dc.description.abstract Aim: Our objective was to evaluate the diagnostic role of dual-phase fluor-18 fluorodeoxyglucose (F-18 FOG) positron emission tomography-computed tomography (PET-CT) and planar lymphoscintigraphy in patients with oral cavity cancer (OCC). We also investigated the combined impact of F-18 FOG PET-CT and sentinel lymph node biopsy (SLNB) in decision making for patients with OCC. Methods: Sixteen patients (4 female, 12 male; age range, 29-81 years) were included in this prospective study. F-18 FDG PET-CT [1 (early) and 2 h (delayed) after injection] and planar lymphoscintigraphy (2 h before the surgery) were performed for all the patients before surgery. The sensitivity, specificity, and negative and positive predictive values in F-18 FOG PET-CT for the early and the delayed scans and tumor/liver uptake (T/L) in the lymph nodes were calculated. Receiver operating characteristic curves were obtained for standardized uptake value (SUV)max and T/L. Results: Histopathological evaluations revealed that 5 patients had metastatic lymph nodes (pN+) whereas 11 patients had benign lymph nodes (pN). Out of 43 lymph nodes visualized as cN(+) in F-18 FDG PET-CT, 14 were pathologically positive for malignancy, whereas 29 were pathologically benign. There was no statistical difference between the N(+) and N(-) patients in terms of age, depth of primary tumor, and the number of mitoses. However, there was a significant difference between the N(+) and N(-) patients (P=.011) in terms of early and delayed F-18 FOG uptake of primary tumors. There was a statistically significant difference in the value of SUVmax between the early and the delayed scans for the malignant lymph nodes (P=.00). Conclusion: This study indicates that F-18 FOG PET-CT is a reliable method for the correct evaluation of primary tumor and N staging in OCCs. Delayed phase of F-18 FOG imaging may increase primary lesion detectability due to higher FDG uptake in primary tumors compared to the early phase of imaging. F-18 FOG PET-CF might demonstrate skip metastasis in lymph nodes which can be missed with SLNB. Although SUV values increased in the delayed phase of F-18 PET-CF imaging in detecting lymph node metastases, the specificity and positive predictive value did not increase. (C) 2015 Elsevier Inc. All rights reserved. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.1016/j.clinimag.2015.02.004
dc.identifier.endpage 786 en_US
dc.identifier.issn 0899-7071
dc.identifier.issn 1873-4499
dc.identifier.issue 5 en_US
dc.identifier.pmid 25721710
dc.identifier.scopus 2-s2.0-84938770637
dc.identifier.scopusquality Q2
dc.identifier.startpage 781 en_US
dc.identifier.uri https://doi.org/10.1016/j.clinimag.2015.02.004
dc.identifier.uri https://hdl.handle.net/20.500.14720/7721
dc.identifier.volume 39 en_US
dc.identifier.wos WOS:000360776900008
dc.identifier.wosquality Q3
dc.language.iso en en_US
dc.publisher Elsevier Science inc en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject F-18 Fdg Pet-Ct en_US
dc.subject Dual Phase en_US
dc.subject Oral Cavity Cancers en_US
dc.subject Planar Lymphoscintigraphy en_US
dc.title Dual-Phase F-18 Fdg Pet-Ct in Staging and Lymphoscintigraphy for Detection of Sentinel Lymph Nodes in Oral Cavity Cancers en_US
dc.type Article en_US

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