Dual-Phase F-18 Fdg Pet-Ct in Staging and Lymphoscintigraphy for Detection of Sentinel Lymph Nodes in Oral Cavity Cancers
dc.authorid | Ada, Emel/0000-0002-0463-0945 | |
dc.authorid | Demir, Yusuf/0000-0001-6762-1977 | |
dc.authorid | Sarioglu, Sulen/0000-0003-4877-3064 | |
dc.authorscopusid | 36195782500 | |
dc.authorscopusid | 56028782100 | |
dc.authorscopusid | 35745637500 | |
dc.authorscopusid | 56526937700 | |
dc.authorscopusid | 55375424200 | |
dc.authorscopusid | 7003736223 | |
dc.authorscopusid | 6603810790 | |
dc.authorwosid | Celik, Ahmet/Iap-5710-2023 | |
dc.authorwosid | Ada, Emel/Aac-3966-2020 | |
dc.authorwosid | Ada, Emel/Aar-7664-2020 | |
dc.authorwosid | Demir, Yusuf/L-2096-2013 | |
dc.authorwosid | Sarioglu, Sulen/F-4706-2011 | |
dc.contributor.author | Surucu, Erdem | |
dc.contributor.author | Polack, Berna Degirmenci | |
dc.contributor.author | Demir, Yusuf | |
dc.contributor.author | Durmusoglu, Mehmet | |
dc.contributor.author | Ekmekci, Sumeyye | |
dc.contributor.author | Sarioglu, Alien | |
dc.contributor.author | Ikiz, Ahmet Omer | |
dc.date.accessioned | 2025-05-10T17:11:52Z | |
dc.date.available | 2025-05-10T17:11:52Z | |
dc.date.issued | 2015 | |
dc.department | T.C. Van Yüzüncü Yıl Üniversitesi | en_US |
dc.department-temp | [Surucu, Erdem; Demir, Yusuf] Yuzuncu Yil Univ, Sch Med, Dept Nucl Med, Van, Turkey; [Polack, Berna Degirmenci] Dokuz Eylul Univ, Sch Med, Dept Nucl Med, Izmir, Turkey; [Durmusoglu, Mehmet; Ikiz, Ahmet Omer] Dokuz Eylul Univ, Sch Med, Dept Ear Eose Throat & Head & Neck Surg, Izmir, Turkey; [Ekmekci, Sumeyye; Sarioglu, Alien] Dokuz Eylul Univ, Sch Med, Dept Pathol, Izmir, Turkey; [Celik, Ahmet Orhan; Ada, Emel] Dokuz Eylul Univ, Sch Med, Dept Radiol, Izmir, Turkey | en_US |
dc.description | Ada, Emel/0000-0002-0463-0945; Demir, Yusuf/0000-0001-6762-1977; Sarioglu, Sulen/0000-0003-4877-3064 | en_US |
dc.description.abstract | Aim: Our objective was to evaluate the diagnostic role of dual-phase fluor-18 fluorodeoxyglucose (F-18 FOG) positron emission tomography-computed tomography (PET-CT) and planar lymphoscintigraphy in patients with oral cavity cancer (OCC). We also investigated the combined impact of F-18 FOG PET-CT and sentinel lymph node biopsy (SLNB) in decision making for patients with OCC. Methods: Sixteen patients (4 female, 12 male; age range, 29-81 years) were included in this prospective study. F-18 FDG PET-CT [1 (early) and 2 h (delayed) after injection] and planar lymphoscintigraphy (2 h before the surgery) were performed for all the patients before surgery. The sensitivity, specificity, and negative and positive predictive values in F-18 FOG PET-CT for the early and the delayed scans and tumor/liver uptake (T/L) in the lymph nodes were calculated. Receiver operating characteristic curves were obtained for standardized uptake value (SUV)max and T/L. Results: Histopathological evaluations revealed that 5 patients had metastatic lymph nodes (pN+) whereas 11 patients had benign lymph nodes (pN). Out of 43 lymph nodes visualized as cN(+) in F-18 FDG PET-CT, 14 were pathologically positive for malignancy, whereas 29 were pathologically benign. There was no statistical difference between the N(+) and N(-) patients in terms of age, depth of primary tumor, and the number of mitoses. However, there was a significant difference between the N(+) and N(-) patients (P=.011) in terms of early and delayed F-18 FOG uptake of primary tumors. There was a statistically significant difference in the value of SUVmax between the early and the delayed scans for the malignant lymph nodes (P=.00). Conclusion: This study indicates that F-18 FOG PET-CT is a reliable method for the correct evaluation of primary tumor and N staging in OCCs. Delayed phase of F-18 FOG imaging may increase primary lesion detectability due to higher FDG uptake in primary tumors compared to the early phase of imaging. F-18 FOG PET-CF might demonstrate skip metastasis in lymph nodes which can be missed with SLNB. Although SUV values increased in the delayed phase of F-18 PET-CF imaging in detecting lymph node metastases, the specificity and positive predictive value did not increase. (C) 2015 Elsevier Inc. All rights reserved. | en_US |
dc.description.woscitationindex | Science Citation Index Expanded | |
dc.identifier.doi | 10.1016/j.clinimag.2015.02.004 | |
dc.identifier.endpage | 786 | en_US |
dc.identifier.issn | 0899-7071 | |
dc.identifier.issn | 1873-4499 | |
dc.identifier.issue | 5 | en_US |
dc.identifier.pmid | 25721710 | |
dc.identifier.scopus | 2-s2.0-84938770637 | |
dc.identifier.scopusquality | Q2 | |
dc.identifier.startpage | 781 | en_US |
dc.identifier.uri | https://doi.org/10.1016/j.clinimag.2015.02.004 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14720/7721 | |
dc.identifier.volume | 39 | en_US |
dc.identifier.wos | WOS:000360776900008 | |
dc.identifier.wosquality | Q3 | |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Science inc | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | F-18 Fdg Pet-Ct | en_US |
dc.subject | Dual Phase | en_US |
dc.subject | Oral Cavity Cancers | en_US |
dc.subject | Planar Lymphoscintigraphy | en_US |
dc.title | Dual-Phase F-18 Fdg Pet-Ct in Staging and Lymphoscintigraphy for Detection of Sentinel Lymph Nodes in Oral Cavity Cancers | en_US |
dc.type | Article | en_US |