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Effects of Protocatechuic Acid Against Cisplatin-Induced Neurotoxicity in Rat Brains: an Experimental Study

dc.authorid Yildirim, Serkan/0000-0003-2457-3367
dc.authorscopusid 15765506300
dc.authorscopusid 58022991700
dc.authorscopusid 37040724900
dc.authorscopusid 16310940800
dc.authorscopusid 6601956926
dc.authorwosid Mis, Leyla/Hhz-3202-2022
dc.authorwosid Yildirim, Serkan/Aah-6721-2020
dc.authorwosid Mert, Handan/Aae-7425-2020
dc.contributor.author Mert, Handan
dc.contributor.author Kerem, Ozge
dc.contributor.author Mis, Leyla
dc.contributor.author Yildirim, Serkan
dc.contributor.author Mert, Nihat
dc.date.accessioned 2025-05-10T17:20:57Z
dc.date.available 2025-05-10T17:20:57Z
dc.date.issued 2024
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Mert, Handan; Kerem, Ozge; Mert, Nihat] Van Yuzuncu Yil Univ, Fac Vet Med, Dept Biochem, Van, Turkiye; [Mis, Leyla] Van Yuzuncu Yil Univ, Fac Vet Med, Dept Physiol, Van, Turkiye; [Yildirim, Serkan] Ataturk Univ, Fac Vet Med, Dept Pathol, Erzurum, Turkiye en_US
dc.description Yildirim, Serkan/0000-0003-2457-3367 en_US
dc.description.abstract Aims/Objectives: Cisplatin (CIS) is widely used in the treatment of various malignant tumors. The aim of study is to determine the potential protective effects of protocatechuic acid (PCA) on the brain in neurotoxicity induced by CIS in rats.Materials and methods: Forty rats were divided into four groups: 1-Control group: 2- PCA group: PCA was administered orally at a dose of 100 mg/kg/day for 5 weeks. 3-CIS group: 5 mg/kg/week of CIS was administered intraperiteonally 4-PCA + CIS group: The rats were given PCA orally daily for 5 weeks and CIS of 5 mg/kg/week. The brain tissues were used for histopathological examinations and for total antioxidant capacity (TAC), total oxidative state (TOS), oxidative stress index (OSI), tumornecrosis factor-alpha (T NF-alpha), interleukin 6 (IL-6) Interleukin 1 beta (IL-1 beta), acetylcholinesterase (AChE), glutamate, gamma aminobutyric acid (GABA), dopamine analyzes in ELISA. WBC, RBC, hemoglobin and hematocrit levels were measured.Results: PCA + CIS group compared to CIS group TOS, OSI, T NF-alpha, IL-6, IL-1 beta, AChE, glutamate, WBC levels decreased significantly, while TAC and GABA levels increased statistically significant. With this study, P CA corrected the deterioration in the oxidant / antioxidant status, suppressed neuro-inflammation, decreased AChE activity, partially normalized neurotransmitters, and decreased the increased WBC count. Necrosis seen in the CIS group in histopathological examinations was never seen in the PCA + CIS group.Conclusions: PCA may provide therapeutic benefit when used in conjunction with CIS. en_US
dc.description.sponsorship [TYL-2020-8805] en_US
dc.description.sponsorship This manuscript is produced from Master Thesis titled 'Investigation of the protective effect of protocatechuic acid against cisplatin-induced neurotoxicity in rats' studied by Ozge KEREM 02/06/2021. We would like to thank to Van YYU Directory of Scientific Research Project Unit who supported to this thesis project (Project Number: TYL-2020-8805). en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.1080/00207454.2022.2147430
dc.identifier.endpage 734 en_US
dc.identifier.issn 0020-7454
dc.identifier.issn 1563-5279
dc.identifier.issue 7 en_US
dc.identifier.pmid 36525373
dc.identifier.scopus 2-s2.0-85144332538
dc.identifier.scopusquality Q2
dc.identifier.startpage 725 en_US
dc.identifier.uri https://doi.org/10.1080/00207454.2022.2147430
dc.identifier.uri https://hdl.handle.net/20.500.14720/10255
dc.identifier.volume 134 en_US
dc.identifier.wos WOS:000898552500001
dc.identifier.wosquality Q4
dc.language.iso en en_US
dc.publisher Taylor & Francis Ltd en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Protocatechuic Acid en_US
dc.subject Cisplatin en_US
dc.subject Oxidative Stress en_US
dc.subject Inflammation en_US
dc.subject Neurotransmitters en_US
dc.subject Hematological Parameters en_US
dc.title Effects of Protocatechuic Acid Against Cisplatin-Induced Neurotoxicity in Rat Brains: an Experimental Study en_US
dc.type Article en_US

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