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Comparison of Icodextrin With Thymoquinone: a New Hope for Postoperative Adhesions

dc.authorid Aras, Abbas/0000-0002-0041-3089
dc.authorid Alp, Hamit Hakan/0000-0002-9202-4944
dc.authorid Yilmaz, Ozkan/0000-0001-7320-0722
dc.authorscopusid 55998916900
dc.authorscopusid 24335444000
dc.authorscopusid 36774252500
dc.authorscopusid 57200256517
dc.authorscopusid 24328770500
dc.authorscopusid 56941615100
dc.authorscopusid 56941615100
dc.authorwosid Aras, Abbas/Hgu-8213-2022
dc.authorwosid Hakan, Hamit/U-2671-2018
dc.contributor.author Yilmaz, O.
dc.contributor.author Kiziltan, R.
dc.contributor.author Celik, S.
dc.contributor.author Yildirm, S.
dc.contributor.author Alp, H. H.
dc.contributor.author Aras, A.
dc.contributor.author Kotan, C.
dc.date.accessioned 2025-05-10T17:03:35Z
dc.date.available 2025-05-10T17:03:35Z
dc.date.issued 2017
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Yilmaz, O.; Kiziltan, R.; Celik, S.; Aras, A.; Kotan, C.] Yuzuncu Yil Univ, Sch Med, Dursun Odabas Med Ctr, Dept Gen Surg, TR-65090 Van, Turkey; [Yildirm, S.] Yuzuncu Yil Univ, Sch Med, Dursun Odabas Med Ctr, Dept Biochem, Van, Turkey; [Alp, H. H.] Yuzuncu Yil Univ, Sch Vet Med, Dept Pathol, Van, Turkey en_US
dc.description Aras, Abbas/0000-0002-0041-3089; Alp, Hamit Hakan/0000-0002-9202-4944; Yilmaz, Ozkan/0000-0001-7320-0722 en_US
dc.description.abstract Objective: The purpose of this study was to compare the effects of thymoquinone and icodextrin in rats within the framework of an experimental adhesion model. Materials and Methods: Rats were separated into three groups: (1) a control group consisting of rats that had 2 ml of isotonic solution administered intraperitoneally, (2) an ICO group administered with 2 ml of 4% icodextrin, and (3) a TQ group administered thymoquinone (10 mg/kg), all following cecal abrasion. The three groups underwent a reoperation on the 7th postoperative day. Hydroxyproline levels were analyzed in the resected adhesive tissues, and histopathological investigations were conducted. Blood samples were collected for biochemical analyses. Results: Fewer postoperative adhesions were observed in the ICO and TQ groups compared with the control group. A comparison of the TQ and ICO groups revealed lowers levels of postoperative adhesions in the TQ group. Compared with the control group, malondialdehyde, 8-OH-deoxyguanosine/deoxyguanosine (8-OHdG/10dG), Coenzyme Q10 (CoQ10), and CoenzymeQ10/reduced CoenzymeQ10 (CoQ10/CoQ10H) values were found to be lower in the TQ and ICO groups. When the TQ and ICO groups were compared with respect to their biochemical parameters, the results for all of the four parameters were found to be statistically significantly lower in the TQ group (P < 0.000). The levels of hydroxyproline in the control, ICO, and TQ groups were found to be (mean +/- standard deviation) 502.25 +/- 90.39 mu g/g, 342.13 +/- 66.61 mu g/g, and 287.88 +/- 49.59 mu g/g, respectively. Conclusions: A comparison of the antiadhesive effects of thymoquinone and icodextrin revealed thymoquinone to be more effective. These results indicate that thymoquinone is an efficient and strong antiadhesive molecule. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.4103/njcp.njcp_209_16
dc.identifier.endpage 1496 en_US
dc.identifier.issn 1119-3077
dc.identifier.issue 11 en_US
dc.identifier.pmid 29303137
dc.identifier.scopus 2-s2.0-85040527079
dc.identifier.scopusquality Q2
dc.identifier.startpage 1489 en_US
dc.identifier.uri https://doi.org/10.4103/njcp.njcp_209_16
dc.identifier.uri https://hdl.handle.net/20.500.14720/5760
dc.identifier.volume 20 en_US
dc.identifier.wos WOS:000422772500018
dc.identifier.wosquality Q4
dc.language.iso en en_US
dc.publisher Medknow Publications & Media Pvt Ltd en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Icodextrin en_US
dc.subject Postoperative Adhesions en_US
dc.subject Rat en_US
dc.subject Thymoquinone en_US
dc.title Comparison of Icodextrin With Thymoquinone: a New Hope for Postoperative Adhesions en_US
dc.type Article en_US

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