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The Role of Pentraxin 3 in Pemphigus Vulgaris

dc.authorid Yavuz, Ibrahim Halil/0000-0003-0819-2871
dc.authorscopusid 55966055600
dc.authorscopusid 57196031370
dc.contributor.author Yavuz, Ibrahim Halil
dc.contributor.author Yavuz, Goknur Ozaydin
dc.date.accessioned 2025-05-10T17:36:15Z
dc.date.available 2025-05-10T17:36:15Z
dc.date.issued 2020
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Yavuz, Ibrahim Halil; Yavuz, Goknur Ozaydin] Van Yuzuncu Yil Univ, Fac Med, Dept Dermatol, Van, Turkey en_US
dc.description Yavuz, Ibrahim Halil/0000-0003-0819-2871 en_US
dc.description.abstract Introduction: Pemphigus is a group of autoimmune bullous diseases caused by antibodies directed against the desmosomal adhesion molecules desmoglein land 3, which are required for intercellular adhesion of keratinocytes. Pentraxins are a group of proteins that function as pattern recognition molecules and also play a role in humoral innate immunity. Pentraxin 3 (PTX3) is the prototype of the long pentraxins and has been shown to be increased in numerous autoimmune diseases. Aim: To investigate whether PTX3 can be used as a marker of PV caused by autoimmunity and resulting in tissue injury. Material and methods: The study included 30 patients who presented to the University Medical School Dermatology Department and were diagnosed with PV based on clinical, histological, and immunological findings. The control group included 30 healthy individuals. Human PTX3 concentration was measured with a commercially available ELISA kit, using a double antibody sandwich enzyme-linked immunosorbent assay. Results: The 60 participants comprised 31 (52%) men and 29 (48%) women. The most common site of onset was mucosa + skin (n = 22; 73.3%) and a psychological pathology was present in 7 (23.3%) patients. Median PTX3 level was significantly higher in the PV group compared to the control group (p = 0.008). The ROC curve analysis indicated a significant area under curve (AUC) value for serum PTX3 level in the prediction of PV. Conclusions: PTX3 was found to be increased in PV and PTX3 could be a useful indicator of disease activity in PV. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.5114/ada.2019.81234
dc.identifier.endpage 507 en_US
dc.identifier.issn 1642-395X
dc.identifier.issue 4 en_US
dc.identifier.pmid 32994770
dc.identifier.scopus 2-s2.0-85090481242
dc.identifier.scopusquality Q3
dc.identifier.startpage 503 en_US
dc.identifier.uri https://doi.org/10.5114/ada.2019.81234
dc.identifier.uri https://hdl.handle.net/20.500.14720/14019
dc.identifier.volume 37 en_US
dc.identifier.wos WOS:000565809700008
dc.identifier.wosquality Q4
dc.language.iso en en_US
dc.publisher Termedia Publishing House Ltd en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Autoimmune en_US
dc.subject Pemphigus en_US
dc.subject Pentraxin 3 en_US
dc.title The Role of Pentraxin 3 in Pemphigus Vulgaris en_US
dc.type Article en_US

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