Comparison of Ketamine, Fentanyl and Remifentanyl in Terms of Sedoanalgesia for Colonoscopy: a Randomized Prospective Double-Blind Study

Abstract

Aim: The aim of this study was to compare the effects of fentanyl, remifentanyl and ketamine applied for analgesia during colonoscopy on hemodynamics and sedo-analgesia quality. Methods: A total of 81 patients, who were scheduled for elective colonoscopy, were included in the study. Groups were randomized according to closed envelope method. Group K received 0.5 mg/kg ketamine, group F, 1 mu g/kg fentanyl, and group R received 1 mu g/kg remifentanil. Anaesthetist administered the analgesic agents at a dose of 1 mL/10 kg body weight without knowing the ingredient. Hemodynamic variables, total amount of propofol consumed, time of the endoscope to reach the cecum, and duration of colonoscopy were recorded. After the procedure, Modified Aldrete Score, patient, colonoscopist and anesthesiologist satisfaction were evaluated. Statistical analysis of the data was performed. Results: The demographic characteristics of the patients included in the study and the distribution of the patients between the groups were similar. There were no significant differences in duration of colonoscopy, hemodynamic changes, oxygen saturation, satisfaction scores, quality of analgesia, recovery and recovery after the procedure between the groups. Conclusion: As a result, ketamine, fentanyl, and remifentanyl applied for analgesia during colonoscopy have similar hemodynamic alterations and analgesic quality, therefore these agents may be substituted for one another for colonoscopy procedures.