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Effect of Lycopene on Serum Nitrite-Nitrate Levels in Diabetic Rats

dc.authorscopusid 55762891900
dc.authorscopusid 6603102677
dc.authorscopusid 23969941600
dc.authorscopusid 55235238500
dc.authorwosid Çetin, Selçuk/Hzi-5950-2023
dc.authorwosid Güder, Aytaç/L-2663-2019
dc.contributor.author Yegin, Sevim C.
dc.contributor.author Yur, Fatmagul
dc.contributor.author Cetin, S.
dc.contributor.author Guder, A.
dc.date.accessioned 2025-05-10T17:37:44Z
dc.date.available 2025-05-10T17:37:44Z
dc.date.issued 2015
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Yegin, Sevim C.; Guder, A.] Giresun Univ, Hlth Serv Vocat Sch Higher Educ, Giresun, Turkey; [Yur, Fatmagul; Cetin, S.] Yuzuncu Yil Univ, Fac Vet Sci, Dept Biol Chem, Van, Turkey en_US
dc.description.abstract The effect of lycopene on serum nitrate-nitrite levels was investigated in diabetic rats. In this investigation, 28 Wistar rats were divided into 4 groups, each of seven rats. These groups were control group, diabetes group, diabetes-lycopene group and lycopene group. The concentration of nitrite and nitrate was detected at high levels in diabetes group, diabetes-lycopene group and lycopene group as compared with the control group (P < 0.05). Especially, the increase in the levels of nitrate in diabetes group and lycopene group was statistically significant when compared with diabetes-lycopene group and control group (P < 0.05). In addition, we also determined the proportion of nitrite/nitrate for nitric oxide radical formation. Therefore, it is important to investigate the recovery and stability of nitrite and nitrate in samples. As a result of this study, it was observed that the amounts of nitrate and nitrite increased due to oxidative stress in diabetes and also application of antioxidant lycopene caused an increase in the amounts of nitrate and nitrite levels. en_US
dc.description.sponsorship Project Management Office of Yuzuncu Yil University [2010-SBE-D115] en_US
dc.description.sponsorship This study is supported by the Project Management Office of Yuzuncu Yil University. The authors are grateful to the Project Management Office of Yuzuncu Yil University (Project no: 2010-SBE-D115). The study protocol was approved by The Local Ethics Committee for Animal Experiments of Yuzuncu Yil University (12 August 2010 and 2010/07 decree no). en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.4103/0250-474X.159676
dc.identifier.endpage 360 en_US
dc.identifier.issn 0250-474X
dc.identifier.issn 1998-3743
dc.identifier.issue 3 en_US
dc.identifier.pmid 26180284
dc.identifier.scopus 2-s2.0-84936157906
dc.identifier.scopusquality N/A
dc.identifier.startpage 357 en_US
dc.identifier.uri https://doi.org/10.4103/0250-474X.159676
dc.identifier.uri https://hdl.handle.net/20.500.14720/14475
dc.identifier.volume 77 en_US
dc.identifier.wos WOS:000361917300016
dc.identifier.wosquality Q4
dc.language.iso en en_US
dc.publisher Medknow Publications & Media Pvt Ltd en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Diabetic Rat en_US
dc.subject Lycopene en_US
dc.subject Nitrite-Nitrate Proportion en_US
dc.title Effect of Lycopene on Serum Nitrite-Nitrate Levels in Diabetic Rats en_US
dc.type Article en_US

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