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Evaluation of the Relationship Between Nasal Septum Deviation and Oxidative Stress Markers

dc.authorscopusid 56312067800
dc.authorscopusid 55062004100
dc.authorscopusid 57208676195
dc.authorscopusid 57210409174
dc.authorscopusid 56259656000
dc.authorwosid Duzenli, Ufuk/X-5141-2018
dc.authorwosid Cetin, Yaser/Aac-8563-2020
dc.contributor.author Duzenli, Ufuk
dc.contributor.author Bozan, Nazim
dc.contributor.author Sonkaya, Yasin
dc.contributor.author Cetin, Yaser Said
dc.contributor.author Demir, Halit
dc.date.accessioned 2025-05-10T17:34:08Z
dc.date.available 2025-05-10T17:34:08Z
dc.date.issued 2019
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Duzenli, Ufuk; Bozan, Nazim; Sonkaya, Yasin] Yuzuncu Yil Univ, Fac Med, Dept Otorhinolaryngol, TR-65080 Van, Turkey; [Cetin, Yaser Said] Van Educ & Res Hosp, Dept Otorhinolaryngol, Van, Turkey; [Demir, Halit] Yuzuncu Yil Univ, Fac Sci, Dept Chem, Van, Turkey en_US
dc.description.abstract Introduction: Nasal septum deviation (NSD) may lead to chronic hypoxia and increased oxidative stress. The main goal of this study was to investigate the effect of NSD on malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), and glutathione (GSH) levels. Methods: There were 30 patients with NSD and 30 healthy subjects in this study. Malondialdehyde, CAT, SOD, and GSH levels were determined in the control and study groups. The measurements were done preoperatively and postoperatively. Study group patients completed the Nasal Obstruction Symptom Evaluation questionnaire preoperatively and postoperatively to determine the success of the septoplasty. Results: Higher CAT, SOD, and GSH levels and lower MDA levels were found in the control group compared with the study group (P<0.05). After septoplasty, Nasal Obstruction Symptom Evaluation scores improved significantly and CAT, SOD, and GSH levels increased significantly (all, P<0.05). Malondialdehyde levels did not decrease significantly after surgery (P>0.05). Conclusions: Nasal obstruction due to nasal septal deviation led to lower antioxidant enzyme levels, and correction of the septum led to an increase in antioxidant levels. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.1097/SCS.0000000000005244
dc.identifier.endpage 853 en_US
dc.identifier.issn 1049-2275
dc.identifier.issn 1536-3732
dc.identifier.issue 3 en_US
dc.identifier.pmid 30892278
dc.identifier.scopus 2-s2.0-85065511290
dc.identifier.scopusquality Q3
dc.identifier.startpage 851 en_US
dc.identifier.uri https://doi.org/10.1097/SCS.0000000000005244
dc.identifier.uri https://hdl.handle.net/20.500.14720/13708
dc.identifier.volume 30 en_US
dc.identifier.wos WOS:000467724100095
dc.identifier.wosquality Q4
dc.language.iso en en_US
dc.publisher Lippincott Williams & Wilkins en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Catalase en_US
dc.subject Glutathione en_US
dc.subject Malondialdehyde en_US
dc.subject Septum Deviation en_US
dc.subject Superoxide Dismutase en_US
dc.title Evaluation of the Relationship Between Nasal Septum Deviation and Oxidative Stress Markers en_US
dc.type Article en_US

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