Investigation of Galectin-3, Lipocalin 2, Retinol Binding Protein (Rbp), Small Dense Low-Density Lipoprotein (Sdldl) in Patients With Hirsutism
dc.authorid | Yavuz, Ibrahim Halil/0000-0003-0819-2871 | |
dc.authorscopusid | 55966055600 | |
dc.authorscopusid | 57196031370 | |
dc.authorscopusid | 56389653700 | |
dc.authorscopusid | 57208899366 | |
dc.authorscopusid | 17134049200 | |
dc.authorwosid | Çokluk, Erdem/Aib-9278-2022 | |
dc.contributor.author | Yavuz, Ibrahim Halil | |
dc.contributor.author | Ozaydin Yavuz, Goknur | |
dc.contributor.author | Cokluk, Erdem | |
dc.contributor.author | Kurtoglu, Zehra | |
dc.contributor.author | Bilgili, Serap Gunes | |
dc.date.accessioned | 2025-05-10T17:43:35Z | |
dc.date.available | 2025-05-10T17:43:35Z | |
dc.date.issued | 2019 | |
dc.department | T.C. Van Yüzüncü Yıl Üniversitesi | en_US |
dc.department-temp | [Yavuz, Ibrahim Halil; Ozaydin-Yavuz, Goknur; Bilgili, Serap Gunes] Van Yuzuncu Yil, Dept Dermatol, Univ Fac Med, Van, Turkey; [Cokluk, Erdem] Yuzuncu Yil Univ, Fac Med, Dept Biochem, Van, Turkey; [Kurtoglu, Zehra] Ankara Res & Training Hosp, Dept Obstet & Gynecol, Ankara, Turkey | en_US |
dc.description | Yavuz, Ibrahim Halil/0000-0003-0819-2871 | en_US |
dc.description.abstract | Introduction: Hirsutism is defined as excessive terminal hair in androgen-dependent areas in women. Adipose tissue is no longer regarded as a storage site for triglycerides or as a source of free fatty acids but is currently emerging as a key constituent of energy metabolism secreting numerous enzymes, cytokines, growth factors, and hormones. Aim: To evaluate serum levels of galectin-3 (Gal3), lipocalin-2 (LCN2), retinol binding protein (RBP), and small dense low-density lipoprotein (sdLDL) in patients with hirsutism and patients co-presenting with polycystic ovary syndrome (PCOS) and hirsutism. Material and methods: The study included 90 patients that were divided into three groups: (I) patients with idiopathic hirsutism (IH) (n = 30), (II) PCOS patients with hirsutism (H-PCOS) (n = 30), and (III) the control group (n = 30). Informed consent was obtained from each participant. Idiopathic hirsutism was scored using the modified Ferriman-Gallwey (mFG) scoring system and the diagnosis of PCOS was established based on the modified Rotterdam criteria. Human Gal3, LCN2, RBP, and sdLDL levels were analysed using a commercially available double-antigen sandwich enzyme-linked immunosorbent assay. Results: No significant difference was found between the three groups with regard to serum Gal3, LCN2, RBP, and sdLDL levels (p > 0.05). Median values were higher in the H-PCOS group than in the other two groups: body weight (median: 76.5 kg) (p < 0.001), waist circumference (median: 82.5 cm) (p = 0.001). Conclusions: No significant correlation was found between the adipokines that play a role in the aetiology of numerous diseases and some mediators of the lipid metabolism and hirsutism. | en_US |
dc.description.sponsorship | Research Fund of the Yuzuncu Yil University | en_US |
dc.description.sponsorship | This work was supported by the Research Fund of the Yuzuncu Yil University. | en_US |
dc.description.woscitationindex | Science Citation Index Expanded | |
dc.identifier.doi | 10.5114/ada.2019.84593 | |
dc.identifier.endpage | 183 | en_US |
dc.identifier.issn | 1642-395X | |
dc.identifier.issue | 2 | en_US |
dc.identifier.pmid | 31320851 | |
dc.identifier.scopus | 2-s2.0-85066070377 | |
dc.identifier.scopusquality | Q3 | |
dc.identifier.startpage | 177 | en_US |
dc.identifier.uri | https://doi.org/10.5114/ada.2019.84593 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14720/15910 | |
dc.identifier.volume | 36 | en_US |
dc.identifier.wos | WOS:000467799900008 | |
dc.identifier.wosquality | Q4 | |
dc.language.iso | en | en_US |
dc.publisher | Termedia Publishing House Ltd | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Hirsutism | en_US |
dc.subject | Polycystic Ovary Syndrome | en_US |
dc.subject | Adipokines | en_US |
dc.title | Investigation of Galectin-3, Lipocalin 2, Retinol Binding Protein (Rbp), Small Dense Low-Density Lipoprotein (Sdldl) in Patients With Hirsutism | en_US |
dc.type | Article | en_US |