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Investigation of Galectin-3, Lipocalin 2, Retinol Binding Protein (Rbp), Small Dense Low-Density Lipoprotein (Sdldl) in Patients With Hirsutism

dc.authorid Yavuz, Ibrahim Halil/0000-0003-0819-2871
dc.authorscopusid 55966055600
dc.authorscopusid 57196031370
dc.authorscopusid 56389653700
dc.authorscopusid 57208899366
dc.authorscopusid 17134049200
dc.authorwosid Çokluk, Erdem/Aib-9278-2022
dc.contributor.author Yavuz, Ibrahim Halil
dc.contributor.author Ozaydin Yavuz, Goknur
dc.contributor.author Cokluk, Erdem
dc.contributor.author Kurtoglu, Zehra
dc.contributor.author Bilgili, Serap Gunes
dc.date.accessioned 2025-05-10T17:43:35Z
dc.date.available 2025-05-10T17:43:35Z
dc.date.issued 2019
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Yavuz, Ibrahim Halil; Ozaydin-Yavuz, Goknur; Bilgili, Serap Gunes] Van Yuzuncu Yil, Dept Dermatol, Univ Fac Med, Van, Turkey; [Cokluk, Erdem] Yuzuncu Yil Univ, Fac Med, Dept Biochem, Van, Turkey; [Kurtoglu, Zehra] Ankara Res & Training Hosp, Dept Obstet & Gynecol, Ankara, Turkey en_US
dc.description Yavuz, Ibrahim Halil/0000-0003-0819-2871 en_US
dc.description.abstract Introduction: Hirsutism is defined as excessive terminal hair in androgen-dependent areas in women. Adipose tissue is no longer regarded as a storage site for triglycerides or as a source of free fatty acids but is currently emerging as a key constituent of energy metabolism secreting numerous enzymes, cytokines, growth factors, and hormones. Aim: To evaluate serum levels of galectin-3 (Gal3), lipocalin-2 (LCN2), retinol binding protein (RBP), and small dense low-density lipoprotein (sdLDL) in patients with hirsutism and patients co-presenting with polycystic ovary syndrome (PCOS) and hirsutism. Material and methods: The study included 90 patients that were divided into three groups: (I) patients with idiopathic hirsutism (IH) (n = 30), (II) PCOS patients with hirsutism (H-PCOS) (n = 30), and (III) the control group (n = 30). Informed consent was obtained from each participant. Idiopathic hirsutism was scored using the modified Ferriman-Gallwey (mFG) scoring system and the diagnosis of PCOS was established based on the modified Rotterdam criteria. Human Gal3, LCN2, RBP, and sdLDL levels were analysed using a commercially available double-antigen sandwich enzyme-linked immunosorbent assay. Results: No significant difference was found between the three groups with regard to serum Gal3, LCN2, RBP, and sdLDL levels (p > 0.05). Median values were higher in the H-PCOS group than in the other two groups: body weight (median: 76.5 kg) (p < 0.001), waist circumference (median: 82.5 cm) (p = 0.001). Conclusions: No significant correlation was found between the adipokines that play a role in the aetiology of numerous diseases and some mediators of the lipid metabolism and hirsutism. en_US
dc.description.sponsorship Research Fund of the Yuzuncu Yil University en_US
dc.description.sponsorship This work was supported by the Research Fund of the Yuzuncu Yil University. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.5114/ada.2019.84593
dc.identifier.endpage 183 en_US
dc.identifier.issn 1642-395X
dc.identifier.issue 2 en_US
dc.identifier.pmid 31320851
dc.identifier.scopus 2-s2.0-85066070377
dc.identifier.scopusquality Q3
dc.identifier.startpage 177 en_US
dc.identifier.uri https://doi.org/10.5114/ada.2019.84593
dc.identifier.uri https://hdl.handle.net/20.500.14720/15910
dc.identifier.volume 36 en_US
dc.identifier.wos WOS:000467799900008
dc.identifier.wosquality Q4
dc.language.iso en en_US
dc.publisher Termedia Publishing House Ltd en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Hirsutism en_US
dc.subject Polycystic Ovary Syndrome en_US
dc.subject Adipokines en_US
dc.title Investigation of Galectin-3, Lipocalin 2, Retinol Binding Protein (Rbp), Small Dense Low-Density Lipoprotein (Sdldl) in Patients With Hirsutism en_US
dc.type Article en_US

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