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The Effects of Melatonin on Oxidative Stress and Prevention of Primordial Follicle Loss Via Activation of Mtor Pathway in the Rat Ovary

dc.authorid Aydin Acar, Cigdem/0000-0002-1311-2314
dc.authorscopusid 57201669290
dc.authorscopusid 8971221500
dc.authorscopusid 55910152400
dc.authorwosid Behram, Yasemin/Aaa-1774-2021
dc.authorwosid Aydın Acar, Çiğdem/N-5410-2018
dc.contributor.author Kandemir, Y. Behram
dc.contributor.author Aydin, C.
dc.contributor.author Gorgisen, G.
dc.date.accessioned 2025-05-10T17:28:46Z
dc.date.available 2025-05-10T17:28:46Z
dc.date.issued 2017
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Kandemir, Y. Behram] Akdeniz Univ, Fac Med, Dept Anat, Antalya, Turkey; [Aydin, C.] Mehmet Akif Ersoy Univ, Bucak Sch Hlth, Dept Nursing, Burdur, Turkey; [Gorgisen, G.] Yuzuncu Yil Univ, Fac Med, Dept Med Biol, Van, Turkey en_US
dc.description Aydin Acar, Cigdem/0000-0002-1311-2314 en_US
dc.description.abstract Mammalian Target of Rapamycin (mTOR) signaling pathway has important roles in the regulation of puberty onset, gonadotropin secretion, follicular development and ovulation. Melatonin (N-acetyl-5-methoxytryptamine) is a lipophilic hormone has multiple functions in regulating the fertility. Recent studies have shown that melatonin affected the number or maturation of follicles in the ovary. The aim of this study was to investigate the effects of melatonin on mTOR expression and quantity of follicle in rat ovary. In the present study, a total of 45 female rats were randomly divided into three groups. Group 1; Control (C), Group 2: Vehicle (V) and Group 3; Melatonin (M). Melatonin was administered intraperitoneally at a dose of 50 mg/kg/day for 30 days in Melatonin group. The effects of Melatonin on the expression of mTOR and downstream components were determined by Western Blot and Reverse Transcriptase PCR analysis. Upon Western Blot and RT-PCR evaluations, we detected higher expression and activation of mTOR, P70S6K, PKCalpha, PCNA and higher numbers of primordial follicles in melatonin group compared with V and C group. In addition to this results, melatonin decreased oxidative stress markers, such as MDA, on the contrary, levels of antioxidative markers, such as CAT and GPx, were increased by melatonin in rat ovary. This study indicated that melatonin may have a significant protective effect on primordial follicles and increase the expression of mTOR and downstream components in rat ovary. Melatonin treatment may have a beneficial effect on fertility. en_US
dc.description.sponsorship Scientific and Technological Research Council of Turkey (TUBITAK) [213S049] en_US
dc.description.sponsorship The authors would like to thank Necdet Demir, Prof. Dr, and Aylin Yaba, Asst. Prof. Dr. for his valuable contributions to this project. The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was partly supported by Scientific and Technological Research Council of Turkey (TUBITAK)-Project 213S049. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.14715/cmb/2017.63.2.16
dc.identifier.endpage 106 en_US
dc.identifier.issn 0145-5680
dc.identifier.issn 1165-158X
dc.identifier.issue 2 en_US
dc.identifier.pmid 28364790
dc.identifier.scopus 2-s2.0-85018726024
dc.identifier.scopusquality Q4
dc.identifier.startpage 100 en_US
dc.identifier.uri https://doi.org/10.14715/cmb/2017.63.2.16
dc.identifier.uri https://hdl.handle.net/20.500.14720/12125
dc.identifier.volume 63 en_US
dc.identifier.wos WOS:000402148700016
dc.identifier.wosquality Q4
dc.language.iso en en_US
dc.publisher C M B Assoc en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Melatonin en_US
dc.subject Mtor en_US
dc.subject Ovary en_US
dc.subject Follicle en_US
dc.subject Infertility en_US
dc.title The Effects of Melatonin on Oxidative Stress and Prevention of Primordial Follicle Loss Via Activation of Mtor Pathway in the Rat Ovary en_US
dc.type Article en_US

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