The Protective Effects of the Lactarius Deliciosus and Agrocybe Cylindracea Mushrooms on Histopathology of Carbon Tetrachloride Induced Oxidative Stress in Rats
| dc.authorid | Dogan, Abdulahad/0000-0002-5438-8560 | |
| dc.authorid | Keles, Omer Faruk/0000-0002-7869-5311 | |
| dc.authorid | Uyar, Ahmet/0000-0003-4345-6756 | |
| dc.authorscopusid | 54893403000 | |
| dc.authorscopusid | 59513304700 | |
| dc.authorscopusid | 57218510411 | |
| dc.authorscopusid | 57195562796 | |
| dc.authorwosid | Uyar, Ahmet/Afm-7697-2022 | |
| dc.authorwosid | Dogan, Abdulahad/Aco-8746-2022 | |
| dc.contributor.author | Dogan, Abdulahad | |
| dc.contributor.author | Uyar, Ahmet | |
| dc.contributor.author | Hasar, Songul | |
| dc.contributor.author | Keles, Omer Faruk | |
| dc.date.accessioned | 2025-05-10T17:10:07Z | |
| dc.date.available | 2025-05-10T17:10:07Z | |
| dc.date.issued | 2022 | |
| dc.department | T.C. Van Yüzüncü Yıl Üniversitesi | en_US |
| dc.department-temp | [Dogan, Abdulahad] Van Yuzuncu Yil Univ, Dept Biochem, Fac Pharm, TR-65080 Van, Turkey; [Uyar, Ahmet] Hatay Mustafa Kemal Univ, Fac Vet Med, Dept Pathol, Antakya, Turkey; [Hasar, Songul] Van Yuzuncu Yil Univ, Inst Nat & Appl Sci, Dept Biol, Van, Turkey; [Keles, Omer Faruk] Van Yuzuncu Yil Univ, Fac Vet Med, Dept Pathol, Van, Turkey | en_US |
| dc.description | Dogan, Abdulahad/0000-0002-5438-8560; Keles, Omer Faruk/0000-0002-7869-5311; Uyar, Ahmet/0000-0003-4345-6756 | en_US |
| dc.description.abstract | We investigated the protective effects of L. deliciosus and A. cylindracea supplementation against carbon tetrachloride (CCI4) induced oxidative stress by measuring levels of adenosine deaminase (ADA) and myeloperoxidase (MPO), and by observing histopathological changes in liver and kidney tissues of rats. We divided 36 rats into six groups: control, CCl4, L. deliciosus, A. cylindracea, CCl4 + L. deliciosus, and CCl4 + A. cylindracea. We found that administration of CCI4, A. cylindracea, and CCl4 + A. cylindracea increased MPO and ADA levels. We observed severe hepato-renal degenerative and necrotic lesions in the CCI4, A. cylindracea and CCl4 + A. cylindracea groups. Severe lesions of the liver and kidney were not observed with A. cylindracea administration. CCI4 induced hepato-renal lesions were ameliorated by L. deliciosus extract supplementation. L. deliciosus could be an important dietary antioxidant for preventing histologic lesions in liver and kidney due to CCI4 induced oxidative stress in rats. | en_US |
| dc.description.sponsorship | Van Yuzuncu Yil University Scientific Research Project Commission [2015-FBE -YL150] | en_US |
| dc.description.sponsorship | This work was funded by the Van Yuzuncu Yil University Scientific Research Project Commission [Grant no: 2015-FBE -YL150]. | en_US |
| dc.description.woscitationindex | Science Citation Index Expanded | |
| dc.identifier.doi | 10.1080/10520295.2021.1918349 | |
| dc.identifier.endpage | 151 | en_US |
| dc.identifier.issn | 1052-0295 | |
| dc.identifier.issn | 1473-7760 | |
| dc.identifier.issue | 2 | en_US |
| dc.identifier.pmid | 33970727 | |
| dc.identifier.scopus | 2-s2.0-85105969388 | |
| dc.identifier.scopusquality | Q3 | |
| dc.identifier.startpage | 143 | en_US |
| dc.identifier.uri | https://doi.org/10.1080/10520295.2021.1918349 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14720/7317 | |
| dc.identifier.volume | 97 | en_US |
| dc.identifier.wos | WOS:000648850100001 | |
| dc.identifier.wosquality | Q4 | |
| dc.language.iso | en | en_US |
| dc.publisher | Taylor & Francis Ltd | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | A | en_US |
| dc.subject | Cylindracea | en_US |
| dc.subject | Carbon Tetrachloride | en_US |
| dc.subject | Histopathology | en_US |
| dc.subject | L | en_US |
| dc.subject | Deliciosus | en_US |
| dc.subject | Mushrooms | en_US |
| dc.subject | Oxidative Stress | en_US |
| dc.subject | Rats | en_US |
| dc.title | The Protective Effects of the Lactarius Deliciosus and Agrocybe Cylindracea Mushrooms on Histopathology of Carbon Tetrachloride Induced Oxidative Stress in Rats | en_US |
| dc.type | Article | en_US |