The Relationship Among Acute-Phase Response Proteins, Cytokines and Hormones in Cachectic Patients With Colon Cancer

Abstract

Backgraund: Acute-phase response proteins (APRP), cytokines and hormones have been claimed to be an independent prognostic factor of malignancies, however the basis for their association with prognosis remains unexplained. We suggest that in colon malignancies, as similar to pancreatic and lung cancers, changes in APRP are associated with angiogenesis. Methods: C-reactive protein (CRP), albumin, IL-1 alpha, IL-1 beta, IL-6, IL-8, IL-10, TNF-alpha, midkine, VEGF-A, VEGF-C, leptin, adiponectin, and ghrelin serum levels are studied in 126 colon cancer patients and 36 healthy subjects. Results: We found statistically significant difference and correlations between two groups. We found significantly higher serum CRP, IL-1 alpha, IL-1 beta,IL-6, IL-8, IL-10, TNF-alpha, VEGF-A, VEGF-C and leptin concentrations in patients relative to controls (p < 0.001). We found lower levels of the serum albumin, midkine, adiponectin and ghrelin in patients compared to control subjects (p < 0.001). Conclusions: Cachexia in patients with colon cancers is associated with changes in APRP, cytokines and hormone concentrations. These biomarkers and cachexia together have a direct relationship with accelerated angiogenesis. This may lead to a connection between the outcomes in malignancies and the biomarkers.