Effects of Curcumin Administration on Nesfatin-1 Levels in Blood, Brain and Fat Tissues of Diabetic Rats
| dc.contributor.author | Algul, S. | |
| dc.contributor.author | Ozcelik, O. | |
| dc.contributor.author | Oto, G. | |
| dc.contributor.author | Sarikaya, M. | |
| dc.contributor.author | Goceroglu, R. T. | |
| dc.contributor.author | Embiyaoglu, N. M. | |
| dc.contributor.author | Akcan, A. G. | |
| dc.date.accessioned | 2025-05-10T17:07:59Z | |
| dc.date.available | 2025-05-10T17:07:59Z | |
| dc.date.issued | 2021 | |
| dc.description | Embiyaoglu, Nuri Mert/0000-0002-1627-8539 | en_US |
| dc.description.abstract | OBJECTIVE: We evaluated the efficacy of curcumin administration on blood glucose levels and its relationship with nesfatin-1 levels in blood brain and adipose tissue of streptozotocin-induced diabetic rats. MATERIALS AND METHODS: A total of 28 male rats were divided into four groups: control group, type 2 diabetes mellitus (DM) group, control plus curcumin group and type 2DM plus curcumin group. After fifteen days, blood samples were collected from sacrificed rats. Nesftain-1 levels were analysed from blood, brain, and fat tissues of rats in all groups. RESULTS: Nesfatin-1 level was found to be significantly lower in blood, brain and fat tissues of type 2 DM rats compared to the control group. A significant decrease in fasting blood glucose levels was observed in the curcumin administration group compared to type 2 DM group. Improvement of fasting blood glucose level was accompanied by improvement of nesfatin-1 levels in blood, brain, and fat tissues. CONCLUSIONS: As expected, curcumin administration caused significant improvement in fasting blood glucose levels. However, for the first time, we found marked improvements in nesfatin-1 levels in blood, brain, and fat tissues of type 2 DM rats. Thus, considering the crucial role of nesfatin-1 in regulation of glucose metabolism, it is logical to expect an interactive relationship between curcumin and nesfatin-1. | en_US |
| dc.description.sponsorship | Van Yuzuncu Yil University Scientific Research Project Office [TLO-2019-7685] | en_US |
| dc.description.sponsorship | This study was supported by Van Yuzuncu Yil University Scientific Research Project Office (Project number: TLO-2019-7685). | en_US |
| dc.identifier.doi | 10.26355/eurrev_202102_24872 | |
| dc.identifier.issn | 1128-3602 | |
| dc.identifier.scopus | 2-s2.0-85101154182 | |
| dc.identifier.uri | https://doi.org/10.26355/eurrev_202102_24872 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14720/6930 | |
| dc.language.iso | en | en_US |
| dc.publisher | verduci Publisher | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Nesfatin-1 | en_US |
| dc.subject | Curcumin | en_US |
| dc.subject | Diabetes | en_US |
| dc.subject | Streptozotocin | en_US |
| dc.subject | Rat | en_US |
| dc.title | Effects of Curcumin Administration on Nesfatin-1 Levels in Blood, Brain and Fat Tissues of Diabetic Rats | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| gdc.author.id | Embiyaoglu, Nuri Mert/0000-0002-1627-8539 | |
| gdc.author.scopusid | 56318101800 | |
| gdc.author.scopusid | 55886751100 | |
| gdc.author.scopusid | 25230277800 | |
| gdc.author.scopusid | 57195476857 | |
| gdc.author.scopusid | 57222050900 | |
| gdc.author.scopusid | 57222039009 | |
| gdc.author.scopusid | 57223042015 | |
| gdc.author.wosid | Sarikaya, Mucahit/Gzk-4637-2022 | |
| gdc.author.wosid | Ozcelik, Oguz/Adw-0044-2022 | |
| gdc.author.wosid | Temelli̇ Göçeroğlu, Rezzan/Izp-5421-2023 | |
| gdc.author.wosid | Embiyaoğlu, Nuri Mert/Grs-3441-2022 | |
| gdc.coar.access | metadata only access | |
| gdc.coar.type | text::journal::journal article | |
| gdc.description.department | T.C. Van Yüzüncü Yıl Üniversitesi | en_US |
| gdc.description.departmenttemp | [Algul, S.; Akcan, A. G.] Van Yuzuncu Yil Univ, Fac Med, Dept Physiol, Van, Turkey; [Ozcelik, O.] Kastamonu Univ, Dept Physiol, Fac Med, Kastamonu, Turkey; [Oto, G.; Goceroglu, R. T.] Van Yuzuncu Yil Univ, Fac Med, Dept Pharmacol, Van, Turkey; [Sarikaya, M.; Embiyaoglu, N. M.; Oner, S.] Van Yuzuncu Yil Univ, Phys Educ & Sports, Van, Turkey; [Caf, F.] Bingol Univ, Tech Sci Vocat High Sch, Bingol, Turkey | en_US |
| gdc.description.endpage | 1621 | en_US |
| gdc.description.issue | 3 | en_US |
| gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| gdc.description.scopusquality | Q2 | |
| gdc.description.startpage | 1616 | en_US |
| gdc.description.volume | 25 | en_US |
| gdc.description.woscitationindex | Science Citation Index Expanded | |
| gdc.description.wosquality | Q2 | |
| gdc.identifier.pmid | 33629331 | |
| gdc.identifier.wos | WOS:000619780200052 | |
| gdc.index.type | WoS | |
| gdc.index.type | Scopus | |
| gdc.index.type | PubMed |