The Effect on Serum Myeloperoxidase Activity and Oxidative Status of Eradication Treatment in Patients Helicobacter Pylori Infected

Abstract

Objectives: Myeloperoxidase activity has been investigated after eradication of Helicobacter pylon (H. pylori) in infected patients in previous studies but the results are controversial. The aim of this study was to investigate effect on serum myeloperoxidase activity and oxidative status of eradication treatment in H. pylon-infected patients. Design and methods: Gastric biopsy specimens were obtained from 30 H. pylori infected patients. Serum Myeloperoxidase activity was measured by enzyme-linked immunoassay. Oxidative status was determined using total antioxidant capacity (TAC) and total oxidant status (TOS) measurement and calculation of oxidative stress index (OSI). Results: After 2 weeks of the eradication treatment, serum myeloperoxidase activity, TOS and OSI values were significantly lower (all: p<0.001), while TAC was significantly higher (p<0.001). Conclusions: Our results indicate that eradication treatment in H. pylori-infected patients may affect both oxidative stress and myeloperoxidase activity which is an important biomarker in pathogenesis of atherosclerosis. (C) 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.