Synthesis and Biological Properties of Novel 1-Methyl Hydrazine Analogues
| dc.contributor.author | Kivrak, Arif | |
| dc.contributor.author | Yilmaz, Can | |
| dc.contributor.author | Konus, Metin | |
| dc.contributor.author | Koca, Halil | |
| dc.contributor.author | Aydemir, Selahattin | |
| dc.contributor.author | Oagaz, Jeger Ali | |
| dc.date.accessioned | 2025-05-10T17:10:53Z | |
| dc.date.available | 2025-05-10T17:10:53Z | |
| dc.date.issued | 2018 | |
| dc.description | Kivrak, Arif/0000-0003-4770-2686; Konus, Metin/0000-0002-9953-1375; Yilmaz, Can/0000-0002-0028-6614 | en_US |
| dc.description.abstract | 1-Methyl-2-(2-(prop-2-yn-1-yloxy)benzylidene)hydrazine analogues were readily prepared in good yields by the reaction of 2-(prop-2-yn-1-yloxy)benzaldehydes and methyl hydrazine. The reaction tolerates a variety of substituents on the 2-hydroxybenzaldehyde to form nitro-, halo-, methoxy-, and naphthyl-substituted 1-methyl-2-(2-(prop-2-yn-1-yloxy)benzylidene)hydrazines. The in vitro antioxidant capacity measurements revealed that among all the analyzed hydrazine analogues that surpassed the Trolox standard, 1-(2-(but-3-ynyl)-5-nitrobenzylidene)-2-methylhydrazine had the maximum value, which was approximately 1.7 times that of Trolox. | en_US |
| dc.description.sponsorship | Van Yuzuncu Yil University [BAP 2013-FEN-B034, 2015-FEN-B280] | en_US |
| dc.description.sponsorship | We thank the Scientific and Technological Research Council of Turkey (TUBITAK 114Z042 and 115Z020) for solvent, salts, and glassware and Van Yuzuncu Yil University (BAP 2013-FEN-B034 and 2015-FEN-B280) for the generous financial support. The authors would like to acknowledge the networking contribution by the COST Action CM1307, "Challenging organic syntheses inspired by nature - from natural products chemistry to drug discovery". | en_US |
| dc.identifier.doi | 10.3906/kim-1701-42 | |
| dc.identifier.issn | 1300-0527 | |
| dc.identifier.scopus | 2-s2.0-85048041741 | |
| dc.identifier.uri | https://doi.org/10.3906/kim-1701-42 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14720/7574 | |
| dc.language.iso | en | en_US |
| dc.publisher | Tubitak Scientific & Technological Research Council Turkey | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Hydrazines | en_US |
| dc.subject | Hydrazones | en_US |
| dc.subject | Abts | en_US |
| dc.subject | Antioxidant Capacities | en_US |
| dc.subject | Biological Properties | en_US |
| dc.title | Synthesis and Biological Properties of Novel 1-Methyl Hydrazine Analogues | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| gdc.author.id | Kivrak, Arif/0000-0003-4770-2686 | |
| gdc.author.id | Konus, Metin/0000-0002-9953-1375 | |
| gdc.author.id | Yilmaz, Can/0000-0002-0028-6614 | |
| gdc.author.scopusid | 8694518300 | |
| gdc.author.scopusid | 57221517895 | |
| gdc.author.scopusid | 56387553800 | |
| gdc.author.scopusid | 57202362619 | |
| gdc.author.scopusid | 57516565000 | |
| gdc.author.scopusid | 57202367529 | |
| gdc.author.wosid | Aydemir, Selahattin/Acx-1253-2022 | |
| gdc.author.wosid | Kivrak, Arif/Aaq-8432-2021 | |
| gdc.author.wosid | Yilmaz, Can/Grs-2754-2022 | |
| gdc.author.wosid | Kivrak, Arif/W-2196-2017 | |
| gdc.coar.access | open access | |
| gdc.coar.type | text::journal::journal article | |
| gdc.description.department | T.C. Van Yüzüncü Yıl Üniversitesi | en_US |
| gdc.description.departmenttemp | [Kivrak, Arif; Koca, Halil; Oagaz, Jeger Ali] Van Yuzuncu Yil Univ, Fac Sci, Dept Chem, Van, Turkey; [Kivrak, Arif] Van Yuzuncu Yil Univ, DOSE Drug R&D, Van, Turkey; [Yilmaz, Can; Konus, Metin; Aydemir, Selahattin] Van Yuzuncu Yil Univ, Fac Sci, Dept Mol Biol & Genet, Van, Turkey | en_US |
| gdc.description.endpage | 316 | en_US |
| gdc.description.issue | 2 | en_US |
| gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| gdc.description.scopusquality | Q3 | |
| gdc.description.startpage | 306 | en_US |
| gdc.description.volume | 42 | en_US |
| gdc.description.woscitationindex | Science Citation Index Expanded | |
| gdc.description.wosquality | Q4 | |
| gdc.identifier.wos | WOS:000431245300009 | |
| gdc.index.type | WoS | |
| gdc.index.type | Scopus | |
| gdc.index.type | TR-Dizin |