The Effectiveness of a Cpg Motif-Based Adjuvant (Cpg Odn 2006) for Lhrh Immunization
| dc.contributor.author | Conforti, Valeria A. | |
| dc.contributor.author | de Avila, David M. | |
| dc.contributor.author | Cummings, Nada S. | |
| dc.contributor.author | Wells, Kenny J. | |
| dc.contributor.author | Uelker, Hasan | |
| dc.contributor.author | Reeves, Jeffy J. | |
| dc.date.accessioned | 2025-05-10T17:29:54Z | |
| dc.date.available | 2025-05-10T17:29:54Z | |
| dc.date.issued | 2007 | |
| dc.description | Ulker, Hasan/0000-0002-7776-3925 | en_US |
| dc.description.abstract | A recombinant ovalbumin-luteinizing hormone-releasing hormone (ova-LHRH) antigen has been developed for immunocontraception. In this study, a novel immunostimulant for ova-LHRH immunization, CpG oligodeoxynucleotide (ODN) 2006, was compared against Mycobacterium butyricum. Also, the immunogenicity of ova-LHRH after lyophilization and exposure to organic solvents was assessed. Rats received either ova-LHRH solubilized in urea; lyophilized ova-LHRH; lyophilized ova-LHRH exposed to methylene chloride; or lyophilized ova-LHRH exposed to ethyl acetate. Immunogenicity of lyophilized ova-LHRH was reduced compared with solubilized ova-LHRH. Exposure to ethyl acetate further decreased immunogenicity of ova-LHRH. CpG ODN 2006 was a more effective immunostimulant than M. butyricum for LHRH immunization. (C) 2007 Elsevier Ltd. All rights reserved. | en_US |
| dc.identifier.doi | 10.1016/j.vaccine.2007.05.056 | |
| dc.identifier.issn | 0264-410X | |
| dc.identifier.scopus | 2-s2.0-34547561125 | |
| dc.identifier.uri | https://doi.org/10.1016/j.vaccine.2007.05.056 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14720/12499 | |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier Sci Ltd | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Lhrh Immunization | en_US |
| dc.subject | Cpg Odn | en_US |
| dc.subject | Alycobacterium Butyricum | en_US |
| dc.title | The Effectiveness of a Cpg Motif-Based Adjuvant (Cpg Odn 2006) for Lhrh Immunization | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| gdc.author.id | Ulker, Hasan/0000-0002-7776-3925 | |
| gdc.author.scopusid | 8980173200 | |
| gdc.author.scopusid | 6602198407 | |
| gdc.author.scopusid | 18133555700 | |
| gdc.author.scopusid | 15023582900 | |
| gdc.author.scopusid | 6507840625 | |
| gdc.author.scopusid | 7403190225 | |
| gdc.coar.access | metadata only access | |
| gdc.coar.type | text::journal::journal article | |
| gdc.description.department | T.C. Van Yüzüncü Yıl Üniversitesi | en_US |
| gdc.description.departmenttemp | Washington State Univ, Dept Anim Sci, Pullman, WA 99164 USA; Yuzunci Yil Univ, Ziraat Fak, Dept Anim Sci, TR-65080 Van, Turkey | en_US |
| gdc.description.endpage | 6543 | en_US |
| gdc.description.issue | 35 | en_US |
| gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| gdc.description.scopusquality | Q2 | |
| gdc.description.startpage | 6537 | en_US |
| gdc.description.volume | 25 | en_US |
| gdc.description.woscitationindex | Science Citation Index Expanded | |
| gdc.description.wosquality | Q2 | |
| gdc.identifier.pmid | 17643561 | |
| gdc.identifier.wos | WOS:000249140300011 | |
| gdc.index.type | WoS | |
| gdc.index.type | Scopus | |
| gdc.index.type | PubMed |