Cpg Motif-Based Adjuvant as a Replacement for Freund's Complete Adjuvant in a Recombinant Lhrh Vaccine
| dc.contributor.author | Conforti, Valeria A. | |
| dc.contributor.author | De Avila, David M. | |
| dc.contributor.author | Curnmings, Nada S. | |
| dc.contributor.author | Zanella, Ricardo | |
| dc.contributor.author | Wells, Kenny J. | |
| dc.contributor.author | Uelker, Hasan | |
| dc.contributor.author | Reeves, Jerry J. | |
| dc.date.accessioned | 2025-05-10T17:26:59Z | |
| dc.date.available | 2025-05-10T17:26:59Z | |
| dc.date.issued | 2008 | |
| dc.description | Ulker, Hasan/0000-0002-7776-3925; Zanella, Ricardo/0000-0003-1449-6708 | en_US |
| dc.description.abstract | This study compared: (1) Freund's complete adjuvant and CpG oligodeoxynucleotide (ODN) 2006 in water-in-oil emulsion as adjuvants; and (2) increasing doses of a recombinant ovalbumin-LHRH (ova-LHRH) fusion protein as an antigen for a contraceptive vaccine. Treatment groups (n = 8 heifers/group) were: one untreated control group; five groups receiving CpG ODN with different doses of ova-LHRH (1.5; 2.3; 3.4; 5.1; and 7.6 mg); and one group receiving 3.4 mg ova-LHRH in Freund's. Heifers were immunized at weeks 0 and 14. Ail vaccine treatments caused gonadal regression and estrus suppression. CpG ODN is a suitable replacement for Freund's for LHRH immunization. (c) 2007 Elsevier Ltd. All rights reserved. | en_US |
| dc.identifier.doi | 10.1016/j.vaccine.2007.12.010 | |
| dc.identifier.issn | 0264-410X | |
| dc.identifier.scopus | 2-s2.0-38649117278 | |
| dc.identifier.uri | https://doi.org/10.1016/j.vaccine.2007.12.010 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14720/11845 | |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier Sci Ltd | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Lhrh Immunization | en_US |
| dc.subject | Cpg Odn | en_US |
| dc.subject | Freund'S Adjuvant | en_US |
| dc.title | Cpg Motif-Based Adjuvant as a Replacement for Freund's Complete Adjuvant in a Recombinant Lhrh Vaccine | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| gdc.author.id | Ulker, Hasan/0000-0002-7776-3925 | |
| gdc.author.id | Zanella, Ricardo/0000-0003-1449-6708 | |
| gdc.author.scopusid | 8980173200 | |
| gdc.author.scopusid | 6602198407 | |
| gdc.author.scopusid | 18133555700 | |
| gdc.author.scopusid | 23098711000 | |
| gdc.author.scopusid | 15023582900 | |
| gdc.author.scopusid | 6507840625 | |
| gdc.author.scopusid | 6507840625 | |
| gdc.author.wosid | Zanella, Ricardo/Aam-8508-2020 | |
| gdc.author.wosid | Zanella, Ricardo/A-4644-2011 | |
| gdc.coar.access | metadata only access | |
| gdc.coar.type | text::journal::journal article | |
| gdc.description.department | T.C. Van Yüzüncü Yıl Üniversitesi | en_US |
| gdc.description.departmenttemp | [Conforti, Valeria A.; De Avila, David M.; Curnmings, Nada S.; Zanella, Ricardo; Wells, Kenny J.; Reeves, Jerry J.] Washington State Univ, Dept Anim Sci, Pullman, WA 99164 USA; [Uelker, Hasan] Yuzuncu Yil Univ, Ziraat Fac, Dept Anim Sci, TR-65080 Van, Turkey | en_US |
| gdc.description.endpage | 913 | en_US |
| gdc.description.issue | 7 | en_US |
| gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| gdc.description.scopusquality | Q2 | |
| gdc.description.startpage | 907 | en_US |
| gdc.description.volume | 26 | en_US |
| gdc.description.woscitationindex | Science Citation Index Expanded | |
| gdc.description.wosquality | Q2 | |
| gdc.identifier.pmid | 18201806 | |
| gdc.identifier.wos | WOS:000253580700007 | |
| gdc.index.type | WoS | |
| gdc.index.type | Scopus | |
| gdc.index.type | PubMed |