The Antioxidant Role of Sideritis Caesarea Infusion Against Tca Toxicity in Rats
| dc.contributor.author | Celik, Ismail | |
| dc.contributor.author | Kaya, Mehmet Salih | |
| dc.date.accessioned | 2025-05-10T17:26:26Z | |
| dc.date.available | 2025-05-10T17:26:26Z | |
| dc.date.issued | 2011 | |
| dc.description.abstract | Sideritis caesarea (SC) Duman, Aytac&Baser is a member of the Lamiaceae family. The present study was designed to investigate the antioxidant properties of the aerial parts of island green tea SC against TCA effects in rats. Biomarkers selected for monitoring antioxidant capacity were the activities of glutathione reductase (GR), superoxide dismutase (SOD), glutathione-S-transferase, catalase (CAT), GSH level and malondialdehyde (MDA) content in various organs of rats. Three experimental groups, A (untreated - control), B (only TCA-treated) and C (TCA + SC-treated), were studied. At the end of the 50 d experiment, the MDA content in tissues increased significantly in group B, whereas no significant changes were observed in group C as compared with that of the control group. Antioxidant enzyme activities such as SOD and CAT increased significantly in the brain, liver and kidneys of group B but decreased significantly in group C as compared with group B. The GSH level and GR activity increased significantly in the brain and liver of group C as compared with the control and TCA-exposed rats. Hence, the study reveals that the constituents present in SC impart protection against chemical-induced oxidative injury that may result in the development of cancer. | en_US |
| dc.description.sponsorship | University of Yuzuncu Yil | en_US |
| dc.description.sponsorship | None of the authors had a commercial interest, financial interest and/or other relationships with manufacturers of pharmaceuticals, laboratory supplies and/or medical devices or with commercial providers of medically related services. The authors are grateful to the University of Yuzuncu Yil Grant Commission for providing financial assistance during the tenure of research. I. C. was the main moderator of the study. I. C. and M. S. K. performed the biochemical investigation and treatment in the present study. | en_US |
| dc.identifier.doi | 10.1017/S0007114510004265 | |
| dc.identifier.issn | 0007-1145 | |
| dc.identifier.issn | 1475-2662 | |
| dc.identifier.scopus | 2-s2.0-79953157830 | |
| dc.identifier.uri | https://doi.org/10.1017/S0007114510004265 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14720/11676 | |
| dc.language.iso | en | en_US |
| dc.publisher | Cambridge Univ Press | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Sideritis Caesarea (Lamiaceae) | en_US |
| dc.subject | Medicinal Food | en_US |
| dc.subject | Tca | en_US |
| dc.subject | Antioxidant Defence Systems | en_US |
| dc.subject | Malondialdehyde | en_US |
| dc.subject | Rats | en_US |
| dc.title | The Antioxidant Role of Sideritis Caesarea Infusion Against Tca Toxicity in Rats | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| gdc.author.scopusid | 8452071500 | |
| gdc.author.scopusid | 55057679700 | |
| gdc.author.wosid | Kaya, Mehmet/Kpa-0011-2024 | |
| gdc.author.wosid | Çelik, İsmail/M-5085-2018 | |
| gdc.coar.access | open access | |
| gdc.coar.type | text::journal::journal article | |
| gdc.description.department | T.C. Van Yüzüncü Yıl Üniversitesi | en_US |
| gdc.description.departmenttemp | [Celik, Ismail; Kaya, Mehmet Salih] Yuzuncu Yil Univ, Fac Arts & Sci, Dept Biol, TR-65080 Van, Turkey | en_US |
| gdc.description.endpage | 668 | en_US |
| gdc.description.issue | 5 | en_US |
| gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| gdc.description.scopusquality | Q2 | |
| gdc.description.startpage | 663 | en_US |
| gdc.description.volume | 105 | en_US |
| gdc.description.woscitationindex | Science Citation Index Expanded | |
| gdc.description.wosquality | Q3 | |
| gdc.identifier.pmid | 21078212 | |
| gdc.identifier.wos | WOS:000287606000002 | |
| gdc.index.type | WoS | |
| gdc.index.type | Scopus | |
| gdc.index.type | PubMed |