Effect of Glucose Concentration on Peritoneal Inflammatory Cytokines in Continuous Ambulatory Peritoneal Dialysis Patients

Abstract

OBJECTIVE : It is known that glucose concentrations of peritoneal dialysis solutions are detrimental to the peritoneal membrane. In order to determine the effect of glucose concentration on cytokine levels of peritoneal fluid of continuous ambulatory peritoneal dialysis (CAPD) patients, a cross-sectional study was performed. Methods: Nine non-diabetic CAPD patients participated in two 8-h dwell sessions of overnight exchanges in consecutive days, with 1.36% and 3.86% glucose containing peritoneal dialysis solutions (Baxter - Eczacibasi). Peritoneal dialysis fluid tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 levels were measured. Results: TNF-alpha levels after 1.36% and 3.86% glucose used dwells were 23 +/- 14 pg/ml and 28 +/- 4 pg/ml, respectively (p = 0.78). The IL-6 levels were 106 +/- 57 pg/ml and 115 +/- 63 pg/ ml ( p = 0.81), respectively. Conclusion: In our in vivo study we found that the glucose concentration of the conventional lactate-based CAPD solution has no effect on basal IL-6 and TNF-alpha levels of peritoneal fluid. Further in vivo studies with non-lactate-based CAPD solutions are needed in order to determine the effect of glucose concentration per se on cytokine release.