Comparative Results of Use and Switching of Anti-Tnf Agents in Adult Behçet's Uveitis

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Date

2024

Journal Title

Journal ISSN

Volume Title

Publisher

Wolters Kluwer Medknow Publications

Abstract

Purpose: This study was planned to compare the clinical results and optical coherence tomography (OCT) data of patients who underwent adalimumab (ADA), infliximab (IFX) and switched protocols between these two methods in cases of Behcet's associated uveitis (BAU). Methods: The patients with BAU who were treated with anti-TNF-alpha agents for at least one year were qualified for the chart review. The outcome parameters were the steroid-free remission state, the best-corrected visual acuity (BCVA), the central macular thickness (CMT), and the subfoveal choroidal thickness (SFCT) of the patients at the last visit. Results: After a mean follow-up of 16.60 months, the rate of active inflammation decreased from 63.6% to 15.1%. Mean BCVA increased, mean CMT and mean SFCT decreased significantly at the last visit (P < 0.001, P < 0.001, respectively). Conclusion: Anti-TNF-alpha treatment and switching protocols between these two agents effectively and safely control intraocular inflammation in BAU patients.

Description

Ozer, Muhammet Derda/0000-0002-3954-270X

Keywords

Anti-Tnf-Alpha, Behcet'S Disease, Biologic Agent, Choroidal Thickness, Intraocular Inflammation, Switched

Turkish CoHE Thesis Center URL

WoS Q

Q2

Scopus Q

Q2

Source

Volume

72

Issue

SUPPL 3

Start Page

S521

End Page

S528