Comparative Results of Use and Switching of Anti-Tnf Agents in Adult Behçet's Uveitis
No Thumbnail Available
Date
2024
Journal Title
Journal ISSN
Volume Title
Publisher
Wolters Kluwer Medknow Publications
Abstract
Purpose: This study was planned to compare the clinical results and optical coherence tomography (OCT) data of patients who underwent adalimumab (ADA), infliximab (IFX) and switched protocols between these two methods in cases of Behcet's associated uveitis (BAU). Methods: The patients with BAU who were treated with anti-TNF-alpha agents for at least one year were qualified for the chart review. The outcome parameters were the steroid-free remission state, the best-corrected visual acuity (BCVA), the central macular thickness (CMT), and the subfoveal choroidal thickness (SFCT) of the patients at the last visit. Results: After a mean follow-up of 16.60 months, the rate of active inflammation decreased from 63.6% to 15.1%. Mean BCVA increased, mean CMT and mean SFCT decreased significantly at the last visit (P < 0.001, P < 0.001, respectively). Conclusion: Anti-TNF-alpha treatment and switching protocols between these two agents effectively and safely control intraocular inflammation in BAU patients.
Description
Ozer, Muhammet Derda/0000-0002-3954-270X
ORCID
Keywords
Anti-Tnf-Alpha, Behcet'S Disease, Biologic Agent, Choroidal Thickness, Intraocular Inflammation, Switched
Turkish CoHE Thesis Center URL
WoS Q
Q2
Scopus Q
Q2
Source
Volume
72
Issue
SUPPL 3
Start Page
S521
End Page
S528