Evaluation of the Relationship Between Nasal Septum Deviation and Oxidative Stress Markers

Abstract

Introduction: Nasal septum deviation (NSD) may lead to chronic hypoxia and increased oxidative stress. The main goal of this study was to investigate the effect of NSD on malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), and glutathione (GSH) levels. Methods: There were 30 patients with NSD and 30 healthy subjects in this study. Malondialdehyde, CAT, SOD, and GSH levels were determined in the control and study groups. The measurements were done preoperatively and postoperatively. Study group patients completed the Nasal Obstruction Symptom Evaluation questionnaire preoperatively and postoperatively to determine the success of the septoplasty. Results: Higher CAT, SOD, and GSH levels and lower MDA levels were found in the control group compared with the study group (P<0.05). After septoplasty, Nasal Obstruction Symptom Evaluation scores improved significantly and CAT, SOD, and GSH levels increased significantly (all, P<0.05). Malondialdehyde levels did not decrease significantly after surgery (P>0.05). Conclusions: Nasal obstruction due to nasal septal deviation led to lower antioxidant enzyme levels, and correction of the septum led to an increase in antioxidant levels.