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Primary Central Nervous System Lymphoma in Daily Practice and the Role of Autologous Stem Cell Transplantation in Relapsed Disease: a Retrospective Multicenter Study

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Date

2016

Journal Title

Journal ISSN

Volume Title

Publisher

Pergamon-elsevier Science Ltd

Abstract

We investigated the course of 54 patients presenting with primary central nervous system lymphoma, who were treated in daily practice. The patients were treated with chemotherapy and/or radiotherapy and/or intrathecal chemotherapy. At a median follow-up period of 23 months (range 1-71), median relapse-free survival (RFS) and overall survival (OS) were not reached. Estimated 2-year RFS and OS rates were 42% and 48%, respectively. Ten relapsed PCNSL patients underwent ASCT. Complete remission rate of these patients was 40%, with 20% treatment-related mortality. Estimated 2-year RFS and OS rates were 37% and 40%, respectively. The prognosis of patients with PCNSL, who received off-study treatment, is still dismal. (c) 2016 Elsevier Ltd. All rights reserved.

Description

Kuku, Irfan/0000-0001-6126-0816; Dogu, Mehmet Hilmi/0000-0001-7237-2637; Demir, Cengiz/0000-0001-9856-184X; Altuntas, Fevzi/0000-0001-6872-3780; Berber, Ilhami/0000-0003-3312-8476; Erkurt, Mehmet Ali/0000-0002-3285-417X; Kaya, Emin/0000-0001-8605-8497

Keywords

Autologous Stem Cell Transplantation, Cns Lymphoma, Pcnsl, Methotrexate, High-Dose Chemotherapy

Turkish CoHE Thesis Center URL

WoS Q

Q4

Scopus Q

Q3

Source

Volume

54

Issue

1

Start Page

80

End Page

84