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Prospective Analysis of Hemorrhagic Cystitis and Bk Viremia in Allogeneic Hematopoietic Stem Cell Transplantation

dc.authorid Tekeli, Alper/0000-0001-9950-9613
dc.authorid Atilla, Erden/0000-0002-8613-2105
dc.authorscopusid 57130839100
dc.authorscopusid 34067476100
dc.authorscopusid 57196320799
dc.authorscopusid 57191595689
dc.authorscopusid 6602421323
dc.authorscopusid 6701422807
dc.authorscopusid 6701422807
dc.authorwosid Uslu, Atilla/Aas-8165-2020
dc.authorwosid Ataca Ati̇lla, Pinar/Aad-4774-2022
dc.authorwosid Topcuoglu, Pervin/Aaq-2986-2020
dc.authorwosid Dolapci, Istar/A-4761-2018
dc.authorwosid Tekeli, Alper/C-3076-2017
dc.contributor.author Atilla, Erden
dc.contributor.author Ates, Can
dc.contributor.author Uslu, Atilla
dc.contributor.author Atilla, Pinar Ataca
dc.contributor.author Dolapci, Istar
dc.contributor.author Tekeli, Alper
dc.contributor.author Topcuoglu, Pervin
dc.date.accessioned 2025-05-10T17:36:15Z
dc.date.available 2025-05-10T17:36:15Z
dc.date.issued 2020
dc.department T.C. Van Yüzüncü Yıl Üniversitesi en_US
dc.department-temp [Atilla, Erden; Uslu, Atilla; Atilla, Pinar Ataca; Topcuoglu, Pervin] Ankara Univ, Dept Hematol, Fac Med, Ankara, Turkey; [Ates, Can] Van Yuzuncu Yil Univ, Dept Biostat, Fac Med, Van, Turkey; [Dolapci, Istar; Tekeli, Alper] Ankara Univ, Dept Microbiol, Fac Med, Ankara, Turkey en_US
dc.description Tekeli, Alper/0000-0001-9950-9613; Atilla, Erden/0000-0002-8613-2105 en_US
dc.description.abstract Objective: BK virus (BKV) infection has been shown to be related to hemorrhagic cystitis (HC) in allogeneic hematopoietic stem cell transplantation (allo-HSCT). There are conflicting data regarding the association between BKV titers in plasma and clinical disease as well as the risk factors for BKV-related HC. Our aim is to study the risk factors and relationship with plasma BK viral load for development of HC in a prospective analysis. Materials and Methods: We prospectively evaluated 59 patients who received allo-HSCT between 2014 and 2016 by quantitative BK virus polymerase chain reaction (PCR) (Altona Diagnostics, Germany) from blood samples at days 0, 30, 60, and 90 after allo-HSCT. The patients were monitored for signs and symptoms of HC. Results: HC was diagnosed in 22 patients (37 %) at a mean of 100 days (range: 0-367 days). In multivariate analysis, the usage of cyclophosphamide (sub-distribution hazard ratio [sdHR]: 7.82, confidence interval [CI]: 1.375-39.645, p=0.02), reactivated CMV (sdHR: 6.105, CI: 1.614-23.094, p=0.008), and positive BKV viremia (sdHR: 2.15, CI: 1.456-22.065, p=0.01) significantly increased the risk of developing HC. Patients with higher viral loads at day 30 and day 60 were diagnosed with more severe HC (p<0.001). Median BK viral loads of >101.5 copies/mL at day 0 (sensitivity 0.727, specificity 0.875), >98.5 copies/mL at day 30 (sensitivity 0.909, specificity 0.875), and >90.0 copies/mL at day 60 (sensitivity 0.909, specificity 0.875) were indicative of HC. Conclusion: Our study showed that administration of cyclophosphamide, CMV reactivation, and BK virus positivity were associated with HC. Plasma BK virus PCR titers at days 0, 30, and 60 after transplant were sensitive tools for predicting clinically proven HC. en_US
dc.description.sponsorship Scientific Projects Department [15B0230007] en_US
dc.description.sponsorship This project was approved by the institutional ethical board on 24 November 2014 and was supported by the Scientific Projects Department, Grant Number 15B0230007. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.4274/tjh.galenos.2019.2019.0296
dc.identifier.endpage 192 en_US
dc.identifier.issn 1300-7777
dc.identifier.issn 1308-5263
dc.identifier.issue 3 en_US
dc.identifier.pmid 31852035
dc.identifier.scopus 2-s2.0-85090078479
dc.identifier.scopusquality Q3
dc.identifier.startpage 186 en_US
dc.identifier.trdizinid 380856
dc.identifier.uri https://doi.org/10.4274/tjh.galenos.2019.2019.0296
dc.identifier.uri https://hdl.handle.net/20.500.14720/14020
dc.identifier.volume 37 en_US
dc.identifier.wos WOS:000564138800006
dc.identifier.wosquality Q3
dc.language.iso en en_US
dc.publisher Galenos Yayincilik en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Hemorrhagic Cystitis en_US
dc.subject Bk Viremia en_US
dc.subject Cytomegalovirus en_US
dc.subject Graft Versus Host Disease en_US
dc.title Prospective Analysis of Hemorrhagic Cystitis and Bk Viremia in Allogeneic Hematopoietic Stem Cell Transplantation en_US
dc.type Article en_US

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