The in Vivo and in Vitro Comparative Nephrotoxicity of Cefazolin and Gentamicin
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Date
1999
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Comparative Toxicology Lab
Abstract
Biochemical, histopathological and cell culture evaluations compared the nephrotoxicity of cefazolin with that of gentamicin. New Zealand rabbits were dosed with 250 mg cefazolin/animal im twice daily, 3 mg gentamicin/kg im twice daily, or 0.9% NaCl solution for 10 d. The rabbits in drug-treated groups had necrosis of proximal kidney tubules and elevated urinary-gamma glutamyl transferase (uGGT) levels. The results of the histopathological examinations, uGGT analyses and effects in cell culture indicated the nephrotoxicities of both antibiotics were similar.
Description
Cabalar, Mehmet/0000-0001-9505-0809
ORCID
Keywords
Turkish CoHE Thesis Center URL
WoS Q
N/A
Scopus Q
N/A
Source
Volume
41
Issue
4
Start Page
222
End Page
225