The in Vivo and in Vitro Comparative Nephrotoxicity of Cefazolin and Gentamicin
| dc.authorid | Cabalar, Mehmet/0000-0001-9505-0809 | |
| dc.authorscopusid | 7103213356 | |
| dc.authorscopusid | 6602855150 | |
| dc.authorscopusid | 6507626108 | |
| dc.authorwosid | Yilmaz, Orhan/Lzg-9973-2025 | |
| dc.authorwosid | Ozbilgin, Sule/R-1336-2019 | |
| dc.authorwosid | Çabalar, Mehmet/Aae-1401-2021 | |
| dc.contributor.author | Yilmaz, O | |
| dc.contributor.author | Cabalar, M | |
| dc.contributor.author | Ozbilgin, S | |
| dc.date.accessioned | 2025-05-10T16:58:41Z | |
| dc.date.available | 2025-05-10T16:58:41Z | |
| dc.date.issued | 1999 | |
| dc.department | T.C. Van Yüzüncü Yıl Üniversitesi | en_US |
| dc.department-temp | Yuzuncu Yil Univ, Dept Pharmacol & Toxicol, Van, Turkey; Yuzuncu Yil Univ, Dept Microbiol, Van, Turkey; Uludag Univ, Dept Pathol, Bursa, Turkey | en_US |
| dc.description | Cabalar, Mehmet/0000-0001-9505-0809 | en_US |
| dc.description.abstract | Biochemical, histopathological and cell culture evaluations compared the nephrotoxicity of cefazolin with that of gentamicin. New Zealand rabbits were dosed with 250 mg cefazolin/animal im twice daily, 3 mg gentamicin/kg im twice daily, or 0.9% NaCl solution for 10 d. The rabbits in drug-treated groups had necrosis of proximal kidney tubules and elevated urinary-gamma glutamyl transferase (uGGT) levels. The results of the histopathological examinations, uGGT analyses and effects in cell culture indicated the nephrotoxicities of both antibiotics were similar. | en_US |
| dc.description.woscitationindex | Science Citation Index Expanded | |
| dc.identifier.endpage | 225 | en_US |
| dc.identifier.issn | 0145-6296 | |
| dc.identifier.issue | 4 | en_US |
| dc.identifier.pmid | 10434375 | |
| dc.identifier.scopus | 2-s2.0-0032794441 | |
| dc.identifier.scopusquality | N/A | |
| dc.identifier.startpage | 222 | en_US |
| dc.identifier.uri | https://hdl.handle.net/20.500.14720/4340 | |
| dc.identifier.volume | 41 | en_US |
| dc.identifier.wos | WOS:000081641900007 | |
| dc.identifier.wosquality | N/A | |
| dc.language.iso | en | en_US |
| dc.publisher | Comparative Toxicology Lab | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.title | The in Vivo and in Vitro Comparative Nephrotoxicity of Cefazolin and Gentamicin | en_US |
| dc.type | Article | en_US |